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Tbio
NOC3L
Nucleolar complex protein 3 homolog

Protein Summary
Description
May be required for adipogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371361
  • ENSP00000360412
  • ENSG00000173145

Symbol
  • AD24
  • C10orf117
  • FAD24
  • AD24
  • FAD24
  • C10orf117
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.9
transcription factor binding site profile
0.84
histone modification site profile
0.66
transcription factor perturbation
0.61
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.26   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.26   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
2
4
94.7
body height
1
1
1
59.5
mean reticulocyte volume
1
1
1
7.2
platelet crit
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
94.7
body height
1
59.5
mean reticulocyte volume
1
7.2
platelet crit
1
0.9
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOC3 like DNA replication regulator
VGNC:7243
450621
Macaque
NOC3 like DNA replication regulator
701132
Mouse
MGI:1932610
57753
Rat
RGD:1560656
361753
Dog
NOC3 like DNA replication regulator
VGNC:43874
100856584
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOC3 like DNA replication regulator
Macaque
NOC3 like DNA replication regulator
Mouse
Rat
Dog
NOC3 like DNA replication regulator
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WTT2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (322)
1 – 10 of 322
MAK16
Tdark
Novelty: 0.07717917
p_int: 0.999671752
p_ni: 0.000328248
Score: 0.986
Data Source: BioPlex,STRINGDB
NOC2L
Tbio
Novelty: 0.00226536
p_int: 0.999419618
p_ni: 0.000580382
Score: 0.977
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.990041415
p_ni: 0.009958585
Score: 0.335
Data Source: BioPlex,STRINGDB
RPL11
Tbio
Novelty: 0.00448962
p_int: 0.980975427
p_ni: 0.019024573
Score: 0.17
Data Source: BioPlex,STRINGDB
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.975426245
p_ni: 0.024573755
Score: 0.513
Data Source: BioPlex,STRINGDB
FGF8
Tbio
Novelty: 0.00155113
p_int: 0.959410146
p_ni: 0.040589854
Data Source: BioPlex
NPM1
Tbio
Novelty: 0.0005485
p_int: 0.948878621
p_ni: 0.051121379
Score: 0.175
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.943498052
p_ni: 0.056501948
Score: 0.928
Data Source: BioPlex,STRINGDB
RPL7L1
Tdark
Novelty: 0.78428937
p_int: 0.932261503
p_ni: 0.067738497
Score: 0.565
Data Source: BioPlex,STRINGDB
PDGFB
Tchem
Novelty: 0.00080876
p_int: 0.923564264
p_ni: 0.076435736
Data Source: BioPlex
Publication Statistics
PubMed Score  19.26

PubMed score by year
PubTator Score  6.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer