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Tchem
SETD7
Histone-lysine N-methyltransferase SETD7

Protein Summary
Description
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274031
  • ENSP00000274031
  • ENSG00000145391

Symbol
  • KIAA1717
  • KMT7
  • SET7
  • SET9
  • KMT7
  • SET7
  • SET9
  • SET7/9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.97
microRNA
0.78
transcription factor binding site profile
0.74
histone modification site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.18   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.18   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (187)
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.762634589
p_ni:  0.23736541
Score:  0.208
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.993
Data Source:  STRINGDB
FOXO3
Tbio
Family:  TF
Novelty:  0.00074316
Score:  0.951
Data Source:  STRINGDB
DNMT1
Tclin
Family:  Enzyme
Novelty:  0.00042336
Score:  0.916
Data Source:  STRINGDB
EED
Tchem
Novelty:  0.00615758
Score:  0.882
Data Source:  STRINGDB
DPY30
Tbio
Novelty:  0.03098629
Score:  0.874
Data Source:  STRINGDB
SUZ12
Tbio
Novelty:  0.00402353
Score:  0.864
Data Source:  STRINGDB
FOXO1
Tbio
Family:  TF
Novelty:  0.00058938
Score:  0.857
Data Source:  STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.856
Data Source:  STRINGDB
CAMKMT
Tbio
Family:  Enzyme
Novelty:  0.00382649
Score:  0.839
Data Source:  STRINGDB
Pathways (8)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET domain containing lysine methyltransferase 7
VGNC:12972
737682
Macaque
SET domain containing lysine methyltransferase 7
700426
Mouse
MGI:1920501
73251
Rat
RGD:1586346
689954
Dog
SET domain containing lysine methyltransferase 7
VGNC:46058
476079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET domain containing lysine methyltransferase 7
Macaque
SET domain containing lysine methyltransferase 7
Mouse
Rat
Dog
SET domain containing lysine methyltransferase 7
Publication Statistics
PubMed Score 180.18
PubMed score by year
PubTator Score 79.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title