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Tbio
ABHD5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5

Protein Summary
Description
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity). The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000644371
  • ENSP00000495778
  • ENSG00000011198
  • ENST00000649763
  • ENSP00000497701

Symbol
  • NCIE2
  • CGI58
  • IECN2
  • NCIE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
disease perturbation
0.79
histone modification site profile
0.76
transcription factor perturbation
0.74
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.73   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.73   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
76.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
76.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 5
VGNC:53351
460303
Macaque
abhydrolase domain containing 5
716821
Mouse
MGI:1914719
67469
Rat
RGD:1303237
316122
Dog
abhydrolase domain containing 5
VGNC:37471
485570
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 5
Macaque
abhydrolase domain containing 5
Mouse
Rat
Dog
abhydrolase domain containing 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WTS1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (64)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride catabolism
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride catabolism
Triglyceride metabolism
Protein-Protein Interactions (89)
1 – 10 of 89
SKAP2
Tbio
Family: Enzyme
Novelty: 0.00614207
p_int: 0.999959669
p_ni: 0.000040326
p_wrong: 5e-9
Score: 0.221
Data Source: BioPlex,STRINGDB
TRIM59
Tbio
Novelty: 0.04240864
p_int: 0.999397112
p_ni: 0.00000608
p_wrong: 0.000596807
Score: 0.333
Data Source: BioPlex,STRINGDB
SARAF
Tbio
Novelty: 0.0383833
p_int: 0.998680851
p_ni: 0.001319147
p_wrong: 1e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
TMEM38B
Tbio
Family: IC
Novelty: 0.0691148
p_int: 0.99857493
p_ni: 0.001336577
p_wrong: 0.000088493
Score: 0.206
Data Source: BioPlex,STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
p_int: 0.998478773
p_ni: 0.001520998
p_wrong: 2.29e-7
Score: 0.185
Data Source: BioPlex,STRINGDB
ZPR1
Tbio
Novelty: 0.01893839
p_int: 0.996169763
p_ni: 0.003830237
Score: 0.258
Data Source: BioPlex,STRINGDB
SNRK
Tbio
Family: Kinase
Novelty: 0.00707197
p_int: 0.989606359
p_ni: 0.005973322
p_wrong: 0.004420319
Score: 0.325
Data Source: BioPlex,STRINGDB
HMOX2
Tchem
Family: Enzyme
Novelty: 0.00180703
p_int: 0.794181389
p_ni: 0.205818611
Score: 0.203
Data Source: BioPlex,STRINGDB
KDM4A
Tchem
Family: Epigenetic
Novelty: 0.00643043
p_int: 0.757873857
p_ni: 0.000169951
p_wrong: 0.241956192
Score: 0.232
Data Source: BioPlex,STRINGDB
PNPLA2
Tchem
Family: Enzyme
Novelty: 0.00149181
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  137.73

PubMed score by year
PubTator Score  64.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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