ZNF473
Zinc finger protein 473
Protein Summary
Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]
- ENST00000270617
- ENSP00000270617
- ENSG00000142528
- ENST00000391821
- ENSP00000375697
- ENST00000595661
- ENSP00000472808
- KIAA1141
- ZFP100
- ZN473
- ZFP100
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
virus perturbation | 0.85 | ||
transcription factor | 0.67 | ||
microRNA | 0.61 | ||
transcription factor binding site profile | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.54 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 117 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.54 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 117 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (47)
Nearest Tclin Targets
Pathways (9)
Reactome (8)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intronless Pre-mRNA | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism of RNA | ||||
Processing of Capped Intronless Pre-mRNA | ||||
RNA Polymerase II Transcription | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | zinc finger protein 473 | VGNC:2164 | 468966 | |||||
Macaque | zinc finger protein 473 | 719168 | ||||||
Mouse | MGI:2442697 | 243963 | ||||||
Rat | RGD:1305084 | 292884 | ||||||
Dog | zinc finger protein 473 | VGNC:49786 | 102156941 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | zinc finger protein 473 | |||||
Macaque | zinc finger protein 473 | |||||
Mouse | ||||||
Rat | ||||||
Dog | zinc finger protein 473 | |||||
Publication Statistics
PubMed Score 8.54
PubMed score by year
PubTator Score 3.89
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
|---|