ZNF473
Zinc finger protein 473
Protein Classes
Protein Summary
Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]
- ENST00000270617
- ENSP00000270617
- ENSG00000142528
- ENST00000391821
- ENSP00000375697
- ENST00000595661
- ENSP00000472808
- KIAA1141
- ZFP100
- ZN473
- ZFP100
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
virus perturbation | 0.85 | ||
transcription factor | 0.67 | ||
microRNA | 0.61 | ||
transcription factor binding site profile | 0.61 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.54 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 117 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.54 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 117 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (9)
Reactome (8)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intronless Pre-mRNA | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism of RNA | ||||
Processing of Capped Intronless Pre-mRNA | ||||
RNA Polymerase II Transcription | ||||
Gene Ontology Terms (9)
Functions (2)
Components (3)
Processes (4)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (47)
1 – 10 of 47
LSM10
Novelty: 0.16403413
Score: 0.978
Data Source: STRINGDB
LSM11
Novelty: 0.10694492
Score: 0.978
Data Source: STRINGDB
SLBP
Novelty: 0.00685735
Score: 0.975
Data Source: Reactome,STRINGDB
SNRPB
Novelty: 0.01503535
Score: 0.912
Data Source: STRINGDB
NCBP1
Novelty: 0.01228885
Score: 0.903
Data Source: Reactome,STRINGDB
ALYREF
Novelty: 0.00523802
Score: 0.903
Data Source: STRINGDB
TRIM28
Family: Epigenetic
Novelty: 0.00778381
Score: 0.903
Data Source: STRINGDB
SNRPD3
Novelty: 0.02022419
Score: 0.901
Data Source: STRINGDB
SNRPE
Novelty: 0.02033423
Score: 0.901
Data Source: STRINGDB
SNRPG
Novelty: 0.1684808
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score 8.54
PubMed score by year
PubTator Score 3.89
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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