Tbio ZNF473 Zinc finger protein 473

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein 473

Protein / ... / Krab Box Transcription Factor / Zinc Finger Protein 473

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger Protein 473

Protein Summary

Description

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q8WTR7
• A8K8T7
• Q9ULS9
• Q9Y4Q7

Gene Name

• ZNF473

Ensembl ID

• ENST00000270617
• ENSP00000270617
• ENSG00000142528
• ENST00000391821
• ENSP00000375697
• ENST00000595661
• ENSP00000472808

Symbol

• KIAA1141
• ZFP100
• ZN473
• ZFP100

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
virus perturbation	0.85
transcription factor	0.67
microRNA	0.61
transcription factor binding site profile	0.61

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (14)

1 – 5 of 14

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (9)

Reactome (8)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Gene Ontology Terms (9)

Functions (2)

Components (3)

Processes (4)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (47)

Explore Interacting Targets

1 – 10 of 47

• See Interactions on String-DB

LSM10

Tbio

Novelty: 0.14178811

Score: 0.978

Data Source: STRINGDB

LSM11

Tbio

Novelty: 0.12170385

Score: 0.978

Data Source: STRINGDB

SLBP

Tbio

Novelty: 0.00692642

Score: 0.975

Data Source: Reactome,STRINGDB

SNRPB

Tbio

Novelty: 0.01137048

Score: 0.912

Data Source: STRINGDB

NCBP1

Tbio

Novelty: 0.00408393

Score: 0.903

Data Source: Reactome,STRINGDB

ALYREF

Tbio

Novelty: 0.00114772

Score: 0.903

Data Source: STRINGDB

TRIM28

Tbio

Family: Epigenetic

Novelty: 0.01042773

Score: 0.903

Data Source: STRINGDB

SNRPD3

Tbio

Novelty: 0.01941268

Score: 0.901

Data Source: STRINGDB

SNRPE

Tbio

Novelty: 0.00150118

Score: 0.901

Data Source: STRINGDB

SNRPG

Tdark

Novelty: 0.75

Score: 0.9

Data Source: STRINGDB

Publication Statistics

PubMed Score  8.54

PubMed score by year

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PubTator Score  3.89

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLDPPRPNLTSHPDGSEDLEPLAGGSP

1-70

EATSPDVTETKNSPLMEDFFEEGFSQEIIEMLSKDGFWNSNFGEACIEDTWLDSLLGDPESLLRSDIATN

70-140

GESPTECKSHELKRGLSPVSTVSTGEDSMVHNVSEKTLTPAKSKEYRGEFFSYSDHSQQDSVQEGEKPYQ

140-210

CSECGKSFSGSYRLTQHWITHTREKPTVHQECEQGFDRNASLSVYPKTHTGYKFYVCNEYGTTFSQSTYL

210-280

WHQKTHTGEKPCKSQDSDHPPSHDTQPGEHQKTHTDSKSYNCNECGKAFTRIFHLTRHQKIHTRKRYECS

280-350

KCQATFNLRKHLIQHQKTHAAKTTSECQECGKIFRHSSLLIEHQALHAGEEPYKCNERGKSFRHNSTLKI

350-420

HQRVHSGEKPYKCSECGKAFHRHTHLNEHRRIHTGYRPHKCQECVRSFSRPSHLMRHQAIHTAEKPYSCA

420-490

ECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICGSTLKCHESVHAREKQGFFVSGKILDQNPEQKEK

490-560

CFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAFGQSTRLIHHQRIHSRVRLYKWGEQGKAISS

560-630

ASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSKCDRVFTQRNYLVQHERTHARKK

630-700

PLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSAELVRHQRIHTGEKPYVCQECGKAFTQS

700-770

SCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVHTQET

770-840

LYQCQRCQKAFRCHSSLSRHQRVHNKQQYCL

840-871

MAEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLDPPRPNLTSHPDGSEDLEPLAGGSPEATSPDVTETKNSPLMEDFFEEGFSQEIIEMLSKDGFWNSNFGEACIEDTWLDSLLGDPESLLRSDIATNGESPTECKSHELKRGLSPVSTVSTGEDSMVHNVSEKTLTPAKSKEYRGEFFSYSDHSQQDSVQEGEKPYQCSECGKSFSGSYRLTQHWITHTREKPTVHQECEQGFDRNASLSVYPKTHTGYKFYVCNEYGTTFSQSTYLWHQKTHTGEKPCKSQDSDHPPSHDTQPGEHQKTHTDSKSYNCNECGKAFTRIFHLTRHQKIHTRKRYECSKCQATFNLRKHLIQHQKTHAAKTTSECQECGKIFRHSSLLIEHQALHAGEEPYKCNERGKSFRHNSTLKIHQRVHSGEKPYKCSECGKAFHRHTHLNEHRRIHTGYRPHKCQECVRSFSRPSHLMRHQAIHTAEKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICGSTLKCHESVHAREKQGFFVSGKILDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAFGQSTRLIHHQRIHSRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSKCDRVFTQRNYLVQHERTHARKKPLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSAELVRHQRIHTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVHTQETLYQCQRCQKAFRCHSSLSRHQRVHNKQQYCL

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Uniprot Keyword

3D-structure
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Ubl conjugation