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Tbio
GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

Protein Summary
Description
Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).[supplied by OMIM, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336898
  • ENSP00000337972
  • ENSG00000158555
  • ENST00000526177
  • ENSP00000434050
  • ENST00000529721
  • ENSP00000433214
  • ENST00000533784
  • ENSP00000437049
  • ENST00000533805
  • ENSP00000435196

Symbol
  • GDE2
  • GDE2
  • PP1665
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
histone modification site profile
0.8
PubMedID
0.73
transcription factor
0.65
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.27   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.27   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (69)
1 – 10 of 69
ROBO1
Tbio
Novelty:  0.00494884
p_int:  0.999995668
p_ni:  0.000004278
p_wrong:  5.5e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
GPD2
Tbio
Family:  Enzyme
Novelty:  0.00951917
p_int:  0.999938094
p_ni:  0.000061906
Score:  0.374
Data Source:  BioPlex,STRINGDB
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
p_int:  0.999869136
p_ni:  0.000130765
p_wrong:  9.9e-8
Data Source:  BioPlex
SELENOT
Tbio
Novelty:  0.02480242
p_int:  0.99971896
p_ni:  0.000277178
p_wrong:  0.000003862
Data Source:  BioPlex
PIP4P2
Tbio
Family:  Enzyme
Novelty:  0.94294105
p_int:  0.999591301
p_ni:  0.000058735
p_wrong:  0.000349964
Data Source:  BioPlex
IGSF8
Tbio
Novelty:  0.03016623
p_int:  0.999401246
p_ni:  0.000598752
p_wrong:  2e-9
Score:  0.165
Data Source:  BioPlex,STRINGDB
LEMD2
Tbio
Novelty:  0.12460123
p_int:  0.998949407
p_ni:  0.001050592
p_wrong:  1e-9
Data Source:  BioPlex
SCAMP4
Tdark
Novelty:  0.20081295
p_int:  0.998087568
p_ni:  0.001906412
p_wrong:  0.00000602
Score:  0.38
Data Source:  BioPlex,STRINGDB
ZMPSTE24
Tbio
Family:  Enzyme
Novelty:  0.0027993
p_int:  0.997431027
p_ni:  0.002568971
p_wrong:  2e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.997347162
p_ni:  0.002652838
Data Source:  BioPlex
Pathways (5)
Glycerophospholipid catabolism (R-HSA-6814848)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid catabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid catabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
4
11
92.8
BMI-adjusted hip circumference
3
3
3
77.1
BMI-adjusted waist circumference
3
2
3
76.2
4
4
4
71.2
waist circumference
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
11
92.8
BMI-adjusted hip circumference
3
77.1
BMI-adjusted waist circumference
3
76.2
4
71.2
waist circumference
1
4.6
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glycerophosphodiester phosphodiesterase domain containing 5
695518
Mouse
MGI:2686926
233552
Rat
RGD:1559673
499211
Dog
glycerophosphodiester phosphodiesterase domain containing 5
VGNC:41170
485188
Horse
glycerophosphodiester phosphodiesterase domain containing 5
VGNC:18299
100064592
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glycerophosphodiester phosphodiesterase domain containing 5
Mouse
Rat
Dog
glycerophosphodiester phosphodiesterase domain containing 5
Horse
glycerophosphodiester phosphodiesterase domain containing 5
Publication Statistics
PubMed Score 24.27
PubMed score by year
PubTator Score 14.82
PubTator score by year