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Tchem
GRK7
Rhodopsin kinase

Protein Summary
Description
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264952
  • ENSP00000264952
  • ENSG00000114124

Symbol
  • GPRK7
  • GPRK7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.93
tissue sample
0.69
cell line
0.49
metabolite
0.45


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.61   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.61   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Herpes simplex virus 2 seropositivity
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Herpes simplex virus 2 seropositivity
1
1.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor kinase 7
714916
Dog
G protein-coupled receptor kinase 7
VGNC:41507
485693
Horse
G protein-coupled receptor kinase 7
VGNC:18598
100062922
Cow
G protein-coupled receptor kinase 7
VGNC:29658
281802
Pig
G protein-coupled receptor kinase 7
397114
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor kinase 7
Dog
G protein-coupled receptor kinase 7
Horse
G protein-coupled receptor kinase 7
Cow
G protein-coupled receptor kinase 7
Pig
G protein-coupled receptor kinase 7
Pathways (18)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (75)
1 – 10 of 75
RHO
Tbio
Family: GPCR
Novelty: 0.00012925
Score: 0.996
Data Source: Reactome,STRINGDB
RCVRN
Tbio
Novelty: 0.00266222
Score: 0.982
Data Source: STRINGDB
ARRB2
Tbio
Novelty: 0.00148149
Score: 0.926
Data Source: STRINGDB
ARRB1
Tbio
Novelty: 0.00262758
Score: 0.901
Data Source: STRINGDB
SAG
Tbio
Novelty: 0.00040944
Score: 0.885
Data Source: STRINGDB
GRK1
Tchem
Family: Kinase
Novelty: 0.00598725
Score: 0.813
Data Source: STRINGDB
GUCA1A
Tbio
Family: Enzyme
Novelty: 0.01003665
Score: 0.762
Data Source: STRINGDB
GUCA1B
Tbio
Family: Enzyme
Novelty: 0.02031715
Score: 0.707
Data Source: STRINGDB
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.675
Data Source: STRINGDB
CXCR4
Tclin
Family: GPCR
Novelty: 0.0002811
Score: 0.675
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.61

PubMed score by year
PubTator Score  62.46

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer