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Tdark
XAGE3
X antigen family member 3

Protein Summary
Description
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346279
  • ENSP00000303061
  • ENSG00000171402
  • ENST00000375491
  • ENSP00000364640

Symbol
  • GAGED4
  • PLAC6
  • PLAC6
  • GAGED4
  • XAGE-3
  • pp9012
  • CT12.3a
  • CT12.3b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.73
cellular component
0.52
cell line
0.51
tissue sample
0.38
interacting protein
0.31


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.67   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.67   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
65.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
65.4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WTP9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (31)
1 – 10 of 31
ZNF644
Tbio
Family:  TF
Novelty:  0.12816167
p_int:  0.999999689
p_ni:  3.11e-7
Data Source:  BioPlex
METAP1D
Tbio
Family:  Enzyme
Novelty:  0.17714714
p_int:  0.99999942
p_ni:  5.79e-7
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
WIZ
Tbio
Family:  TF
Novelty:  0.04458547
p_int:  0.999999129
p_ni:  8.71e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
EHMT2
Tchem
Family:  Epigenetic
Novelty:  0.00262578
p_int:  0.999999043
p_ni:  9.47e-7
p_wrong:  9e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
EHMT1
Tchem
Family:  Epigenetic
Novelty:  0.00821799
p_int:  0.999998883
p_ni:  0.000001117
Score:  0.167
Data Source:  BioPlex,STRINGDB
GAST
Tbio
Novelty:  0.00011795
p_int:  0.999961321
p_ni:  0.000038679
Score:  0.558
Data Source:  BioPlex,STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.999937089
p_ni:  0.000062911
Data Source:  BioPlex
GTSE1
Tbio
Family:  Enzyme
Novelty:  0.0460569
p_int:  0.999498938
p_ni:  0.000496412
p_wrong:  0.000004651
Score:  0.311
Data Source:  BioPlex,STRINGDB
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.99869976
p_ni:  0.000733929
p_wrong:  0.000566311
Score:  0.165
Data Source:  BioPlex,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.998675164
p_ni:  0.001295249
p_wrong:  0.000029588
Data Source:  BioPlex
Publication Statistics
PubMed Score  6.67

PubMed score by year
PubTator Score  0.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer