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Tchem
HASPIN
Serine/threonine-protein kinase haspin

Protein Summary
Description
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325418
  • ENSP00000325290
  • ENSG00000177602

Symbol
  • GSG2
  • GSG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.56   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.56   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (109)
1 – 10 of 109
P4HA3
Tbio
Family: Enzyme
Novelty: 0.04334371
p_int: 0.999961436
p_ni: 0.000038564
Data Source: BioPlex
RPL28
Tbio
Novelty: 0.0322797
p_int: 0.997875551
p_ni: 0.002103056
p_wrong: 0.000021393
Data Source: BioPlex
APP
Tchem
Novelty: 0.00011446
p_int: 0.995342641
p_ni: 0.004602987
p_wrong: 0.000054372
Data Source: BioPlex
EEF1D
Tbio
Novelty: 0.0317015
p_int: 0.984027731
p_ni: 0.015745806
p_wrong: 0.000226463
Data Source: BioPlex
RAD51
Tchem
Novelty: 0.00014377
p_int: 0.983752938
p_ni: 0.016236848
p_wrong: 0.000010214
Score: 0.213
Data Source: BioPlex,STRINGDB
PNMA2
Tbio
Novelty: 0.00097197
p_int: 0.981608607
p_ni: 0.017694204
p_wrong: 0.000697189
Data Source: BioPlex
RBM4B
Tdark
Novelty: 0.88888889
p_int: 0.981268672
p_ni: 0.018277944
p_wrong: 0.000453384
Data Source: BioPlex
CTR9
Tbio
Family: Enzyme
Novelty: 0.05343122
p_int: 0.980849764
p_ni: 0.019150234
p_wrong: 2e-9
Score: 0.33
Data Source: BioPlex,STRINGDB
SIRT6
Tchem
Family: Epigenetic
Novelty: 0.00185315
p_int: 0.976836221
p_ni: 0.022989286
p_wrong: 0.000174493
Data Source: BioPlex
HECTD3
Tdark
Family: Enzyme
p_int: 0.967420481
p_ni: 0.032579519
Data Source: BioPlex
Publication Statistics
PubMed Score  48.56

PubMed score by year
PubTator Score  40.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer