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Tchem
HASPIN
Serine/threonine-protein kinase haspin

Protein Summary
Description
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325418
  • ENSP00000325290
  • ENSG00000177602

Symbol
  • GSG2
  • GSG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.23   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.23   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone H3 associated protein kinase
VGNC:9314
748101
Mouse
MGI:1194498
14841
Rat
RGD:1596276
687827
Dog
histone H3 associated protein kinase
VGNC:49092
611109
Cow
histone H3 associated protein kinase
767819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone H3 associated protein kinase
Mouse
Rat
Dog
histone H3 associated protein kinase
Cow
histone H3 associated protein kinase
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TF76-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (109)
1 – 10 of 109
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
p_int: 0.999961436
p_ni: 0.000038564
Data Source: BioPlex
RPL28
Tbio
Novelty: 0.03136035
p_int: 0.997875551
p_ni: 0.002103056
p_wrong: 0.000021393
Data Source: BioPlex
APP
Tchem
Novelty: 0.00008964
p_int: 0.995342641
p_ni: 0.004602987
p_wrong: 0.000054372
Data Source: BioPlex
EEF1D
Tbio
Novelty: 0.02480745
p_int: 0.984027731
p_ni: 0.015745806
p_wrong: 0.000226463
Data Source: BioPlex
RAD51
Tchem
Novelty: 0.00011516
p_int: 0.983752938
p_ni: 0.016236848
p_wrong: 0.000010214
Score: 0.213
Data Source: BioPlex,STRINGDB
PNMA2
Tbio
Novelty: 0.00162709
p_int: 0.981608607
p_ni: 0.017694204
p_wrong: 0.000697189
Data Source: BioPlex
RBM4B
Tdark
Novelty: 0.33151475
p_int: 0.981268672
p_ni: 0.018277944
p_wrong: 0.000453384
Data Source: BioPlex
CTR9
Tbio
Family: Enzyme
Novelty: 0.04434964
p_int: 0.980849764
p_ni: 0.019150234
p_wrong: 2e-9
Score: 0.33
Data Source: BioPlex,STRINGDB
SIRT6
Tchem
Family: Epigenetic
Novelty: 0.00155366
p_int: 0.976836221
p_ni: 0.022989286
p_wrong: 0.000174493
Data Source: BioPlex
HECTD3
Tdark
Family: Enzyme
Novelty: 2.20874654
p_int: 0.967420481
p_ni: 0.032579519
Data Source: BioPlex
Publication Statistics
PubMed Score  66.23

PubMed score by year
PubTator Score  40.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer