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Tbio
SHROOM3
Protein Shroom3

Protein Summary
Description
Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296043
  • ENSP00000296043
  • ENSG00000138771

Symbol
  • KIAA1481
  • SHRML
  • SHRM
  • APXL3
  • ShrmL
  • MSTP013
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
trait
0.93
PubMedID
0.88
transcription factor perturbation
0.88
protein complex
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.31   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.31   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
5
9
18
95.5
hematocrit
4
3
4
93
creatinine measurement
5
3
5
92.6
red blood cell density measurement
2
2
2
91
hemoglobin measurement
3
1
3
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
18
95.5
hematocrit
4
93
creatinine measurement
5
92.6
red blood cell density measurement
2
91
hemoglobin measurement
3
82.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (42)
1 – 10 of 42
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
Score: 0.754
Data Source: STRINGDB
SOWAHB
Tdark
Novelty: 1.09724527
Score: 0.738
Data Source: STRINGDB
MYH10
Tbio
Novelty: 0.00624251
Score: 0.67
Data Source: STRINGDB
SH3RF1
Tbio
Family: Enzyme
Novelty: 0.01836588
Score: 0.67
Data Source: STRINGDB
SPATA5L1
Tdark
Family: Enzyme
Novelty: 0.5393372
Score: 0.67
Data Source: STRINGDB
NECTIN3
Tbio
Novelty: 0.01288113
Score: 0.649
Data Source: STRINGDB
ELFN2
Tdark
Family: Enzyme
Novelty: 0.40013413
Score: 0.641
Data Source: STRINGDB
UMOD
Tbio
Novelty: 0.00153334
Score: 0.571
Data Source: STRINGDB
DCDC1
Tbio
Novelty: 0.21703566
Score: 0.57
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.31

PubMed score by year
PubTator Score  33.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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