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Tbio
ZNF384
Zinc finger protein 384

Protein Summary
Description
Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319770
  • ENSP00000321650
  • ENSG00000126746
  • ENST00000355772
  • ENSP00000348018
  • ENST00000361959
  • ENSP00000354592
  • ENST00000396801
  • ENSP00000380019

Symbol
  • CAGH1
  • CIZ
  • NMP4
  • TNRC1
  • NP
  • CIZ
  • NMP4
  • CAGH1
  • ERDA2
  • TNRC1
  • CAGH1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor
0.73
virus perturbation
0.68
biological process
0.64
microRNA
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.32   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.32   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
9
86.1
high density lipoprotein cholesterol measurement
1
2
2
79.2
mean corpuscular volume
1
1
1
57.3
red blood cell distribution width
1
1
1
56.8
triglyceride measurement
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
86.1
high density lipoprotein cholesterol measurement
2
79.2
mean corpuscular volume
1
57.3
red blood cell distribution width
1
56.8
triglyceride measurement
1
53.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 384
VGNC:13500
451790
Macaque
zinc finger protein 384
722077
Mouse
MGI:2443203
269800
Rat
RGD:708346
171018
Dog
zinc finger protein 384
VGNC:48713
486723
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 384
Macaque
zinc finger protein 384
Mouse
Rat
Dog
zinc finger protein 384
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TF68-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (66)
1 – 10 of 66
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.950928254
p_ni:  0.049071746
Score:  0.22
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.803009442
p_ni:  0.196990557
p_wrong:  1e-9
Score:  0.365
Data Source:  BioPlex,STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.904
Data Source:  STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.825
Data Source:  STRINGDB
TLX1
Tbio
Family:  TF
Novelty:  0.00619542
Score:  0.825
Data Source:  STRINGDB
DNAJC6
Tbio
Family:  Enzyme
Novelty:  0.01359669
Score:  0.822
Data Source:  STRINGDB
INTS1
Tbio
Novelty:  0.17523407
Score:  0.822
Data Source:  STRINGDB
ABCA3
Tbio
Family:  Transporter
Novelty:  0.00376503
Score:  0.819
Data Source:  STRINGDB
ALG3
Tbio
Family:  Enzyme
Novelty:  0.0159047
Score:  0.818
Data Source:  STRINGDB
ALMS1
Tbio
Novelty:  0.00694228
Score:  0.818
Data Source:  STRINGDB
Publication Statistics
PubMed Score  84.32

PubMed score by year
PubTator Score  28.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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