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Tdark
GIPC2
PDZ domain-containing protein GIPC2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370759
  • ENSP00000359795
  • ENSG00000137960

Symbol
  • SEMCAP2
  • SEMCAP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
histone modification site profile
0.76
tissue
0.62
cell line
0.61
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.59   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.59   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
3
10
96.3
self reported educational attainment
3
3
3
89.8
body height
3
2
3
84.8
red blood cell distribution width
2
2
2
65.7
diastolic blood pressure
1
1
1
65
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
10
96.3
self reported educational attainment
3
89.8
body height
3
84.8
red blood cell distribution width
2
65.7
diastolic blood pressure
1
65
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1889209
54120
Rat
RGD:1560751
365960
Dog
GIPC PDZ domain containing family member 2
VGNC:41226
490200
Horse
GIPC PDZ domain containing family member 2
VGNC:50839
100066247
Cow
GIPC PDZ domain containing family member 2
VGNC:29366
518246
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
GIPC PDZ domain containing family member 2
Horse
GIPC PDZ domain containing family member 2
Cow
GIPC PDZ domain containing family member 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (32)
1 – 10 of 32
SH3BP4
Tbio
Novelty: 0.13130398
p_int: 0.999925701
p_ni: 0.000074296
p_wrong: 3e-9
Score: 0.573
Data Source: BioPlex,STRINGDB
APPL1
Tbio
Novelty: 0.00973424
p_int: 0.844490038
p_ni: 0.155509962
Score: 0.496
Data Source: BioPlex,STRINGDB
MYO6
Tbio
Novelty: 0.01073438
Score: 0.853
Data Source: STRINGDB
FZD3
Tbio
Family: GPCR
Novelty: 0.00964507
Score: 0.733
Data Source: STRINGDB
RGS19
Tchem
Novelty: 0.0159403
Score: 0.676
Data Source: STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.649
Data Source: STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
Score: 0.531
Data Source: STRINGDB
GH2
Tbio
Novelty: 0.00071871
Score: 0.514
Data Source: STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.508
Data Source: STRINGDB
MYO5B
Tbio
Novelty: 0.01302142
Score: 0.493
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.59

PubMed score by year
PubTator Score  3.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer