Tbio ZFP90 Zinc finger protein 90 homolog

Protein Summary

Description

Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. Isoform 2: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg). This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Uniprot Accession IDs

• Q8TF47
• B2RU00
• B3KVE7
• L7S2P3
• Q49AD1
• Q96MQ6
• Zfp-90

Gene Name

• ZFP90

Ensembl ID

• ENST00000398253
• ENSP00000381304
• ENSG00000184939
• ENST00000563169
• ENSP00000454418
• ENST00000570495
• ENSP00000460547
• ENST00000611381
• ENSP00000480309

Symbol

• KIAA1954
• ZNF756
• FIK
• NK10
• ZNF756
• zfp-90

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
biological process	0.64
trait	0.61
transcription factor perturbation	0.61
transcription factor binding site profile	0.6

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein 90 Homolog

Protein / ... / Krab Box Transcription Factor / Zinc Finger Protein 90 Homolog

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger Protein 90 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.08   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.08   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0