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Tdark
ZNF431
Zinc finger protein 431

Protein Summary
Description
Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311048
  • ENSP00000308578
  • ENSG00000196705

Symbol
  • KIAA1969
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.69
molecular function
0.63
microRNA
0.59
biological process
0.58
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.05   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.05   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (13)
1 – 10 of 13
TYRP1
Tbio
Family: Enzyme
Novelty: 0.00062138
p_int: 0.999812218
p_ni: 0.000187775
p_wrong: 7e-9
Score: 0.689
Data Source: BioPlex,STRINGDB
APP
Tchem
Novelty: 0.00008964
p_int: 0.999136427
p_ni: 0.000008381
p_wrong: 0.000855191
Data Source: BioPlex
ICAM3
Tbio
Novelty: 0.00213474
p_int: 0.953367488
p_ni: 4.1e-8
p_wrong: 0.046632471
Score: 0.416
Data Source: BioPlex,STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.846419207
p_ni: 0.000076757
p_wrong: 0.153504036
Score: 0.192
Data Source: BioPlex,STRINGDB
ZNF512
Tbio
Family: TF
Novelty: 0.08783629
p_int: 0.82238248
p_ni: 0.00005003
p_wrong: 0.17756749
Data Source: BioPlex
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.904
Data Source: STRINGDB
GLB1L2
Tdark
Family: Enzyme
Novelty: 1.03866932
Score: 0.515
Data Source: STRINGDB
CREG2
Tdark
Novelty: 0.83142703
Score: 0.511
Data Source: STRINGDB
SREK1IP1
Tdark
Novelty: 1.39429464
Score: 0.497
Data Source: STRINGDB
SFXN3
Tbio
Novelty: 0.18698456
Score: 0.474
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.05

PubMed score by year
PubTator Score  0.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer