Tbio DYNLRB2 Dynein light chain roadblock-type 2

Protein Summary

Description

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Uniprot Accession IDs

• Q8TF09

Gene Name

• DYNLRB2

Ensembl ID

• ENST00000305904
• ENSP00000302936
• ENSG00000168589

Symbol

• DNCL2B
• DNLC2B
• ROBLD2
• DNCL2B
• DNLC2B
• ROBLD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
gene perturbation	0.76
tissue sample	0.74
transcription factor binding site profile	0.57
transcription factor	0.55

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Dynein Light Chain Roadblock-type 2

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Dynein Light Chain Roadblock-type 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.18   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.18   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0