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Tbio
PAQR8
Membrane progestin receptor beta

Protein Summary
Description
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360726
  • ENSP00000353953
  • ENSG00000170915
  • ENST00000442253
  • ENSP00000406197

Symbol
  • C6orf33
  • LMPB1
  • MPRB
  • MPRB
  • LMPB1
  • C6orf33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
transcription factor binding site profile
0.73
cell type or tissue
0.67
kinase perturbation
0.66
microRNA
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.72   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.72   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
32
interleukin 7 measurement
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
32
interleukin 7 measurement
1
26.3
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
EFHC1
Tbio
Novelty: 0.01722469
Score: 0.903
Data Source: STRINGDB
CTSD
Tchem
Family: Enzyme
Novelty: 0.00029823
Score: 0.71
Data Source: STRINGDB
PGRMC2
Tbio
Novelty: 0.01069278
Score: 0.679
Data Source: STRINGDB
PGRMC1
Tbio
Novelty: 0.00364386
Score: 0.669
Data Source: STRINGDB
ADIPOQ
Tbio
Novelty: 0.00011196
Score: 0.652
Data Source: STRINGDB
DPM3
Tdark
Family: Enzyme
Novelty: 0.05248147
Score: 0.631
Data Source: STRINGDB
PIGW
Tbio
Novelty: 0.0245774
Score: 0.631
Data Source: STRINGDB
PPP4R2
Tbio
Family: Enzyme
Novelty: 0.15136638
Score: 0.628
Data Source: STRINGDB
MCM3
Tbio
Novelty: 0.00593382
Score: 0.566
Data Source: STRINGDB
MMD2
Tbio
Novelty: 0.07096035
Score: 0.56
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.72

PubMed score by year
PubTator Score  8.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer