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Tbio
USP33
Ubiquitin carboxyl-terminal hydrolase 33

Protein Summary
Description
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting ly ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357428
  • ENSP00000350009
  • ENSG00000077254
  • ENST00000370792
  • ENSP00000359828
  • ENST00000370793
  • ENSP00000359829
  • ENST00000370794
  • ENSP00000359830

Symbol
  • KIAA1097
  • VDU1
  • VDU1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
co-expressed gene
0.76
disease perturbation
0.74
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.4   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.4   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.99997322
p_ni:  0.00002678
Score:  0.15
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999966384
p_ni:  0.000033616
Score:  0.318
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999462284
p_ni:  0.000537715
p_wrong:  1e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
STN1
Tbio
Novelty:  0.01309587
p_int:  0.993032148
p_ni:  0.006967851
p_wrong:  1e-9
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.990321232
p_ni:  0.009678767
Data Source:  BioPlex
APBA2
Tbio
Novelty:  0.01654185
p_int:  0.982701139
p_ni:  0.017298859
p_wrong:  2e-9
Data Source:  BioPlex
TKTL2
Tbio
Family:  Enzyme
Novelty:  0.0915871
p_int:  0.973615322
p_ni:  0.026384677
p_wrong:  1e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
VSX2
Tbio
Family:  TF
Novelty:  0.0046733
p_int:  0.969562731
p_ni:  0.030436653
p_wrong:  6.16e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
TMEM134
Tdark
Novelty:  0.42629221
p_int:  0.966258052
p_ni:  0.033741912
p_wrong:  3.6e-8
Data Source:  BioPlex
CTAG2
Tbio
Novelty:  0.02983879
p_int:  0.959427523
p_ni:  0.040567826
p_wrong:  0.000004652
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Deubiquitination
Reactome
Developmental Biology
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Axon guidance
Deubiquitination
Developmental Biology
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
78.7
platelet count
1
1
1
44.2
hip circumference
1
1
1
35
waist circumference
1
1
1
30.2
calcium measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
78.7
platelet count
1
44.2
hip circumference
1
35
waist circumference
1
30.2
calcium measurement
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 33
VGNC:10902
456965
Mouse
MGI:2159711
170822
Rat
RGD:1307848
310960
Dog
ubiquitin specific peptidase 33
VGNC:48189
479984
Horse
ubiquitin specific peptidase 33
VGNC:24842
100053171
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 33
Mouse
Rat
Dog
ubiquitin specific peptidase 33
Horse
ubiquitin specific peptidase 33
Publication Statistics
PubMed Score 27.40
PubMed score by year
PubTator Score 19.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title