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Tbio
CREB3L4
Cyclic AMP-responsive element-binding protein 3-like protein 4

Protein Summary
Description
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271889
  • ENSP00000271889
  • ENSG00000143578
  • ENST00000368600
  • ENSP00000357589
  • ENST00000368603
  • ENSP00000357592
  • ENST00000368607
  • ENSP00000357596

Symbol
  • AIBZIP
  • CREB4
  • JAL
  • JAL
  • hJAL
  • ATCE1
  • CREB3
  • CREB4
  • AIBZIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.7
virus perturbation
0.68
cell type or tissue
0.67
gene perturbation
0.65
histone modification site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.33   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.33   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (173)
CREB3 factors activate genes (R-HSA-8874211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CREB3 factors activate genes
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
CREB3 factors activate genes
Metabolism of proteins
Unfolded Protein Response (UPR)
Protein-Protein Interactions (80)
1 – 10 of 80
MBTPS1
Tchem
Family: Enzyme
Novelty: 0.00845881
Score: 0.952
Data Source: Reactome,STRINGDB
MBTPS2
Tbio
Family: Enzyme
Novelty: 0.00625665
Score: 0.947
Data Source: Reactome,STRINGDB
CREB3
Tbio
Family: TF
Novelty: 0.00424318
Score: 0.912
Data Source: STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.894
Data Source: STRINGDB
CREB5
Tbio
Family: TF
Novelty: 0.03857106
Score: 0.889
Data Source: STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.884
Data Source: STRINGDB
CREB3L1
Tbio
Family: TF
Novelty: 0.02295608
Score: 0.851
Data Source: STRINGDB
CREB3L2
Tbio
Family: TF
Novelty: 0.0284456
Score: 0.847
Data Source: STRINGDB
CRTC2
Tbio
Novelty: 0.01888215
Score: 0.846
Data Source: STRINGDB
ATF6B
Tbio
Family: TF
Novelty: 0.07061573
Score: 0.832
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.33

PubMed score by year
PubTator Score  15.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer