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Tbio
PARD3
Partitioning defective 3 homolog

Protein Summary
Description
Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340077
  • ENSP00000341844
  • ENSG00000148498
  • ENST00000346874
  • ENSP00000340591
  • ENST00000350537
  • ENSP00000311986
  • ENST00000374776
  • ENSP00000363908
  • ENST00000374788
  • ENSP00000363920
  • ENST00000374789
  • ENSP00000363921
  • ENST00000374794
  • ENSP00000363926
  • ENST00000545260
  • ENSP00000440857
  • ENST00000545693
  • ENSP00000443147

Symbol
  • PAR3
  • PAR3A
  • Baz
  • ASIP
  • PAR3
  • PARD-3
  • PARD3A
  • SE2-5T2
  • PPP1R118
  • SE2-5L16
  • SE2-5LT1
  • PAR3alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
virus perturbation
0.88
biological process
0.87
drug perturbation
0.87
PubMedID
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.9   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.9   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
PARD6B
Tbio
Novelty:  0.08495161
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
RASSF8
Tbio
Novelty:  0.09245647
p_int:  0.999999998
p_ni:  2e-9
Score:  0.828
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.999107586
p_ni:  0.000892392
p_wrong:  2.2e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
MYL6
Tbio
Novelty:  0.00594485
p_int:  0.960530336
p_ni:  0.039466341
p_wrong:  0.000003323
Data Source:  BioPlex
RASSF7
Tbio
Novelty:  0.08011259
p_int:  0.89536576
p_ni:  0.015582858
p_wrong:  0.089051382
Score:  0.75
Data Source:  BioPlex,STRINGDB
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
Score:  0.999
Data Source:  Reactome,STRINGDB
PARD6A
Tbio
Novelty:  0.05667035
Score:  0.996
Data Source:  Reactome,STRINGDB
PARD6G
Tbio
Novelty:  0.23553331
Score:  0.994
Data Source:  Reactome,STRINGDB
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
Score:  0.978
Data Source:  Reactome,STRINGDB
F11R
Tbio
Novelty:  0.00182817
Score:  0.978
Data Source:  Reactome,STRINGDB
Pathways (106)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Signal Transduction
Reactome
Signaling by TGF-beta Receptor Complex
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Signal Transduction
Signaling by TGF-beta Receptor Complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
71.4
serum gamma-glutamyl transferase measurement
1
1
1
70.9
self reported educational attainment
1
1
1
54.4
FEV/FEC ratio
1
1
1
51.7
glomerular filtration rate
2
2
1
5.7
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
71.4
serum gamma-glutamyl transferase measurement
1
70.9
self reported educational attainment
1
54.4
FEV/FEC ratio
1
51.7
glomerular filtration rate
1
5.7
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
par-3 family cell polarity regulator
VGNC:7854
450398
Macaque
par-3 family cell polarity regulator
706472
Mouse
MGI:2135608
93742
Rat
RGD:620374
81918
Dog
par-3 family cell polarity regulator
VGNC:44263
477953
Species
Name
OMA
EggNOG
Inparanoid
Chimp
par-3 family cell polarity regulator
Macaque
par-3 family cell polarity regulator
Mouse
Rat
Dog
par-3 family cell polarity regulator
Publication Statistics
PubMed Score 207.90
PubMed score by year
PubTator Score 146.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title