Pharos: Illuminating the Druggable Genome

Tbio

Protein Summary

Description

Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants ...more

Uniprot Accession IDs

Gene Name

PARD3

Ensembl ID

ENST00000340077
ENSP00000341844
ENSG00000148498
ENST00000346874
ENSP00000340591
ENST00000350537
ENSP00000311986
ENST00000374776
ENSP00000363908
ENST00000374788
ENSP00000363920
ENST00000374789
ENSP00000363921
ENST00000374794
ENSP00000363926
ENST00000545260
ENSP00000440857
ENST00000545693
ENSP00000443147

Symbol

PAR3
PAR3A
Baz
ASIP
PAR3
PARD-3
PARD3A
SE2-5T2
PPP1R118
SE2-5L16
SE2-5LT1
PAR3alpha

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96

virus perturbation	0.88

biological process	0.87

drug perturbation	0.87

PubMedID	0.83

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.39 (req: < 5)

View Publications

Gene RIFs: 54 (req: <= 3)

View Gene RIFs

Antibodies: 218 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.39 (req: >= 5)

Gene RIFs: 54 (req: > 3)

Antibodies: 218 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (106)

Reactome (8)

KEGG (9)

PathwayCommons (3)

WikiPathways (86)

Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell junction organization	88 targets	R-HSA-446728

Reactome	Cell-Cell communication	121 targets	R-HSA-1500931

Reactome	Cell-cell junction organization	63 targets	R-HSA-421270

Reactome	Signal Transduction	2704 targets	R-HSA-162582

Reactome	Signaling by TGF-beta Receptor Complex	73 targets	R-HSA-170834

Name	Explore in Pharos	Explore in Source
Cell junction organization	88 targets	R-HSA-446728

Cell-Cell communication	121 targets	R-HSA-1500931

Cell-cell junction organization	63 targets	R-HSA-421270

Signal Transduction	2704 targets	R-HSA-162582

Signaling by TGF-beta Receptor Complex	73 targets	R-HSA-170834

Gene Ontology Terms (42)

Functions (6)

Components (17)

Processes (19)

Items per page:

1 – 6 of 6

GO Term	Evidence	Assigned by
phosphatidylinositol binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

phosphatidylinositol-3,4,5-trisphosphate binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

phosphatidylinositol-3-phosphate binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

phosphatidylinositol-4,5-bisphosphate binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

identical protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

protein phosphatase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (166)

1 – 10 of 166

See Interactions on String-DB

PARD6B

Tbio

Novelty: 0.11958639

p_int: 0.999999999

p_ni: 1e-9

Score: 0.998

Data Source: BioPlex,Reactome,STRINGDB

RASSF8

Tbio

Novelty: 0.08828757

p_int: 0.999999998

p_ni: 2e-9

Score: 0.828

Data Source: BioPlex,STRINGDB

PSMC3

Tbio

Family: Enzyme

Novelty: 0.0502828

p_int: 0.999107586

p_ni: 0.000892392

p_wrong: 2.2e-8

Score: 0.213

Data Source: BioPlex,STRINGDB

MYL6

Tbio

Novelty: 0.00785422

p_int: 0.960530336

p_ni: 0.039466341

p_wrong: 0.000003323

Data Source: BioPlex

RASSF7

Tbio

Novelty: 0.10160843

p_int: 0.89536576

p_ni: 0.015582858

p_wrong: 0.089051382

Score: 0.75

Data Source: BioPlex,STRINGDB

PRKCI

Tchem

Family: Kinase

Novelty: 0.01104604

Score: 0.999