Pharos : Target Details

Tbio

Protein Summary

Description

Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants ...more

Uniprot Accession IDs

Gene Name

PARD3

Ensembl ID

ENST00000340077
ENSP00000341844
ENSG00000148498
ENST00000346874
ENSP00000340591
ENST00000350537
ENSP00000311986
ENST00000374776
ENSP00000363908
ENST00000374788
ENSP00000363920
ENST00000374789
ENSP00000363921
ENST00000374794
ENSP00000363926
ENST00000545260
ENSP00000440857
ENST00000545693
ENSP00000443147

Symbol

PAR3
PAR3A
Baz
ASIP
PAR3
PARD-3
PARD3A
SE2-5T2
PPP1R118
SE2-5L16
SE2-5LT1
PAR3alpha

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96

virus perturbation	0.88

biological process	0.87

drug perturbation	0.87

PubMedID	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.9 (req: < 5)

View Publications

Gene RIFs: 54 (req: <= 3)

View Gene RIFs

Antibodies: 218 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.9 (req: >= 5)

Gene RIFs: 54 (req: > 3)

Antibodies: 218 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (166)

Explore Interacting Targets

1 – 10 of 166

See Interactions on String-DB

PARD6B

Tbio

Novelty: 0.08495161

p_int: 0.999999999

p_ni: 1e-9

Score: 0.998

Data Source: BioPlex,Reactome,STRINGDB

RASSF8

Tbio

Novelty: 0.09245647

p_int: 0.999999998

p_ni: 2e-9

Score: 0.828

Data Source: BioPlex,STRINGDB

PSMC3

Tbio

Family: Enzyme

Novelty: 0.04026019

p_int: 0.999107586

p_ni: 0.000892392

p_wrong: 2.2e-8

Score: 0.213

Data Source: BioPlex,STRINGDB

MYL6

Tbio

Novelty: 0.00594485

p_int: 0.960530336

p_ni: 0.039466341

p_wrong: 0.000003323

Data Source: BioPlex

RASSF7

Tbio

Novelty: 0.08011259

p_int: 0.89536576

p_ni: 0.015582858

p_wrong: 0.089051382

Score: 0.75

Data Source: BioPlex,STRINGDB

PRKCI

Tchem

Family: Kinase

Novelty: 0.0076377

Score: 0.999