PARD3
Partitioning defective 3 homolog
Protein Summary
Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants ...more
- ENST00000340077
- ENSP00000341844
- ENSG00000148498
- ENST00000346874
- ENSP00000340591
- ENST00000350537
- ENSP00000311986
- ENST00000374776
- ENSP00000363908
- ENST00000374788
- ENSP00000363920
- ENST00000374789
- ENSP00000363921
- ENST00000374794
- ENSP00000363926
- ENST00000545260
- ENSP00000440857
- ENST00000545693
- ENSP00000443147
- PAR3
- PAR3A
- Baz
- ASIP
- PAR3
- PARD-3
- PARD3A
- SE2-5T2
- PPP1R118
- SE2-5L16
- SE2-5LT1
- PAR3alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.96 | ||
virus perturbation | 0.88 | ||
biological process | 0.87 | ||
drug perturbation | 0.87 | ||
PubMedID | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 250.46 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 218 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 250.46 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 218 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (166)
PARD6B
Novelty: 0.08495161
p_int: 0.999999999
p_ni: 1e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RASSF8
Novelty: 0.09245647
p_int: 0.999999998
p_ni: 2e-9
Score: 0.828
Data Source: BioPlex,STRINGDB
PSMC3
Family: Enzyme
Novelty: 0.04026019
p_int: 0.999107586
p_ni: 0.000892392
p_wrong: 2.2e-8
Score: 0.213
Data Source: BioPlex,STRINGDB
MYL6
Novelty: 0.00594485
p_int: 0.960530336
p_ni: 0.039466341
p_wrong: 0.000003323
Data Source: BioPlex
RASSF7
Novelty: 0.08011259
p_int: 0.89536576
p_ni: 0.015582858
p_wrong: 0.089051382
Score: 0.75
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (3)
1 – 3 of 3
Pathways (106)
Reactome (8)
KEGG (9)
PathwayCommons (3)
WikiPathways (86)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by TGF-beta Receptor Complex | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Signal Transduction | ||||
Signaling by TGF-beta Receptor Complex | ||||
Viral Interactions (0)
Gene Ontology Terms (42)
Functions (6)
Components (17)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 75.1 | |||||
mathematical ability | 3 | 2 | 3 | 74.8 | |||||
educational attainment | 1 | 3 | 3 | 71.5 | |||||
brain measurement | 1 | 1 | 0 | 9.8 | 65.5 | ||||
glomerular filtration rate | 3 | 3 | 2 | 5.7 | 63.8 | ||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 75.1 | |||||
mathematical ability | 3 | 74.8 | |||||
educational attainment | 3 | 71.5 | |||||
brain measurement | 0 | 9.8 | 65.5 | ||||
glomerular filtration rate | 2 | 5.7 | 63.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | par-3 family cell polarity regulator | VGNC:7854 | 450398 | |||||
Macaque | par-3 family cell polarity regulator | 706472 | ||||||
Mouse | MGI:2135608 | 93742 | ||||||
Rat | RGD:620374 | 81918 | ||||||
Dog | par-3 family cell polarity regulator | VGNC:44263 | 477953 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | par-3 family cell polarity regulator | |||||
Macaque | par-3 family cell polarity regulator | |||||
Mouse | ||||||
Rat | ||||||
Dog | par-3 family cell polarity regulator | |||||
Publication Statistics
PubMed Score 250.46
PubMed score by year
PubTator Score 146.01
PubTator score by year
Related Publications
Text Mined References (106)
GeneRif Annotations (54)
Items per page:
0 of 0
PMID | Year | Title |
|---|