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Tbio
RAPGEF6
Rap guanine nucleotide exchange factor 6

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296859
  • ENSP00000296859
  • ENSG00000158987
  • ENST00000308008
  • ENSP00000311419
  • ENST00000507093
  • ENSP00000426081
  • ENST00000509018
  • ENSP00000421684
  • ENST00000510071
  • ENSP00000425389
  • ENST00000627212
  • ENSP00000487439

Symbol
  • PDZGEF2
  • RAGEF2
  • PDZGEF2
  • KIA001LB
  • PDZ-GEF2
  • RA-GEF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.95
transcription factor perturbation
0.8
histone modification site profile
0.76
cell line
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.25   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.25   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
1
3
81.8
mathematical ability
1
1
1
73.5
BMI-adjusted waist-hip ratio
1
1
1
57.1
wellbeing measurement
1
1
1
41.5
1
1
0
1
36.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
81.8
mathematical ability
1
73.5
BMI-adjusted waist-hip ratio
1
57.1
wellbeing measurement
1
41.5
0
1
36.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 6
743392
Mouse
MGI:2384761
192786
Rat
RGD:1307645
303141
Dog
Rap guanine nucleotide exchange factor 6
609521
Horse
Rap guanine nucleotide exchange factor 6
100063392
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 6
Mouse
Rat
Dog
Rap guanine nucleotide exchange factor 6
Horse
Rap guanine nucleotide exchange factor 6
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TEU7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (48)
1 – 10 of 48
RAPGEF2
Tbio
Novelty: 0.03353183
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.809
Data Source: BioPlex,STRINGDB
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.999999299
p_ni: 7.01e-7
Data Source: BioPlex
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.999861854
p_ni: 0.000122085
p_wrong: 0.000016061
Data Source: BioPlex
SOWAHB
Tdark
Novelty: 1.09724527
p_int: 0.992200695
p_ni: 0.005222923
p_wrong: 0.002576382
Data Source: BioPlex
APBA3
Tbio
Novelty: 0.05059532
p_int: 0.986296749
p_ni: 0.001151513
p_wrong: 0.012551738
Score: 0.257
Data Source: BioPlex,STRINGDB
RARRES1
Tbio
Family: Enzyme
Novelty: 0.04701793
p_int: 0.977696543
p_ni: 0.010379028
p_wrong: 0.011924429
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.937663593
p_ni: 0.000285279
p_wrong: 0.062051128
Data Source: BioPlex
GRN
Tbio
Novelty: 0.00096395
p_int: 0.898511909
p_ni: 0.00008873
p_wrong: 0.10139936
Score: 0.183
Data Source: BioPlex,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.962
Data Source: STRINGDB
MRAS
Tbio
Family: Enzyme
Novelty: 0.01544981
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.25

PubMed score by year
PubTator Score  9.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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