Tbio RAPGEF6 Rap guanine nucleotide exchange factor 6

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.

Uniprot Accession IDs

• Q8TEU7
• A3KN82
• A5PLL6
• B7ZML2
• E9PDV7
• Q8NI21
• Q8TEU6
• Q96PC1

Gene Name

• RAPGEF6

Ensembl ID

• ENST00000296859
• ENSP00000296859
• ENSG00000158987
• ENST00000308008
• ENSP00000311419
• ENST00000507093
• ENSP00000426081
• ENST00000509018
• ENSP00000421684
• ENST00000510071
• ENSP00000425389
• ENST00000627212
• ENSP00000487439

Symbol

• PDZGEF2
• RAGEF2
• PDZGEF2
• KIA001LB
• PDZ-GEF2
• RA-GEF-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor binding site profile	0.95
transcription factor perturbation	0.8
histone modification site profile	0.76
cell line	0.71

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Rap Guanine Nucleotide Exchange Factor 6

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Rap Guanine Nucleotide Exchange Factor 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.92   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.92   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0