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Tbio
GEMIN5
Gem-associated protein 5

Protein Summary
Description
Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:16857593, PubMed:18984161, PubMed:20513430). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:18984161). GEMIN5 acts as the snRNA-binding protein of the SMN complex (PubMed:1171 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285873
  • ENSP00000285873
  • ENSG00000082516

Symbol
  • GEMIN-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
ligand (protein) perturbation
0.83
interacting protein
0.82
kinase perturbation
0.81
microRNA
0.7


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.06   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.06   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 5
VGNC:6878
471715
Macaque
gem nuclear organelle associated protein 5
714864
Mouse
MGI:2449311
216766
Rat
RGD:1586275
691231
Dog
gem nuclear organelle associated protein 5
VGNC:41175
479321
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 5
Macaque
gem nuclear organelle associated protein 5
Mouse
Rat
Dog
gem nuclear organelle associated protein 5
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TEQ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (124)
1 – 10 of 124
SNRPA1
Tbio
Novelty: 0.01232044
p_int: 0.99999161
p_ni: 0.00000839
Score: 0.766
Data Source: BioPlex,STRINGDB
GEMIN7
Tbio
Novelty: 0.04835353
p_int: 0.999991422
p_ni: 0.000008578
Score: 0.985
Data Source: BioPlex,STRINGDB
GAR1
Tbio
Novelty: 0.26091307
p_int: 0.999990493
p_ni: 0.000009507
Score: 0.509
Data Source: BioPlex,STRINGDB
SNRPB2
Tbio
Novelty: 0.17219587
p_int: 0.999962651
p_ni: 0.000037349
Data Source: BioPlex
AKR1D1
Tbio
Family: Enzyme
Novelty: 0.01264297
p_int: 0.999908165
p_ni: 0.000091835
Score: 0.228
Data Source: BioPlex,STRINGDB
DDX20
Tbio
Family: Enzyme
Novelty: 0.01854078
p_int: 0.999873533
p_ni: 0.000126467
Score: 0.995
Data Source: BioPlex,STRINGDB
SNRPB
Tbio
Novelty: 0.01503535
p_int: 0.999800788
p_ni: 0.000199212
Score: 0.956
Data Source: BioPlex,STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.99971712
p_ni: 0.00028288
Score: 0.651
Data Source: BioPlex,STRINGDB
STRAP
Tbio
Family: Enzyme
Novelty: 0.0336013
p_int: 0.999699475
p_ni: 0.000300525
Score: 0.985
Data Source: BioPlex,STRINGDB
SNRPN
Tbio
Novelty: 0.002157
p_int: 0.998828479
p_ni: 0.001171521
Score: 0.315
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  27.06

PubMed score by year
PubTator Score  20.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer