CEP192
Centrosomal protein of 192 kDa
Protein Summary
Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804).
- ENST00000506447
- ENSP00000427550
- ENSG00000101639
- KIAA1569
- PPP1R62
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
tissue | 0.69 | ||
virus perturbation | 0.68 | ||
cellular component | 0.64 | ||
cell line | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.62 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 54 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.62 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 54 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (148)
AURKA
Family: Kinase
Novelty: 0.0010868
p_int: 0.999999753
p_ni: 1.64e-7
p_wrong: 8.3e-8
Score: 0.994
Data Source: BioPlex,STRINGDB
DCTPP1
Family: Enzyme
Novelty: 0.05521767
p_int: 0.999994796
p_ni: 0.000005195
p_wrong: 9e-9
Score: 0.517
Data Source: BioPlex,STRINGDB
FEZ1
Novelty: 0.02695814
p_int: 0.999633319
p_ni: 0.000366645
p_wrong: 3.6e-8
Score: 0.546
Data Source: BioPlex,STRINGDB
HOMER3
Novelty: 0.04408998
p_int: 0.9993818
p_ni: 0.000618148
p_wrong: 5.1e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
CARD8
Family: Enzyme
Novelty: 0.0146799
p_int: 0.998901687
p_ni: 0.001096783
p_wrong: 0.00000153
Data Source: BioPlex
GMNN
Novelty: 0.00436572
p_int: 0.991122315
p_ni: 0.002196976
p_wrong: 0.006680709
Score: 0.264
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (18)
Reactome (16)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Centrosome maturation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Anchoring of the basal body to the plasma membrane | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Centrosome maturation | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (1)
Components (4)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 1 | 3 | 75 | |||||
self reported educational attainment | 3 | 2 | 2 | 5.8 | 55.8 | ||||
intelligence | 5 | 3 | 2 | 5.5 | 42.2 | ||||
C-reactive protein measurement | 1 | 1 | 1 | 38.2 | |||||
heel bone mineral density | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 75 | |||||
self reported educational attainment | 2 | 5.8 | 55.8 | ||||
intelligence | 2 | 5.5 | 42.2 | ||||
C-reactive protein measurement | 1 | 38.2 | |||||
heel bone mineral density | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | centrosomal protein 192 | VGNC:5149 | 468602 | |||||
Mouse | MGI:1918049 | 70799 | ||||||
Dog | centrosomal protein 192 [Source:HGNC Symbol;Acc:HGNC:25515] | |||||||
Horse | centrosomal protein 192 | VGNC:50928 | 100057580 | |||||
Cow | centrosomal protein 192 | VGNC:27199 | 104975778 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | centrosomal protein 192 | |||||
Mouse | ||||||
Dog | centrosomal protein 192 [Source:HGNC Symbol;Acc:HGNC:25515] | |||||
Horse | centrosomal protein 192 | |||||
Cow | centrosomal protein 192 | |||||
Publication Statistics
PubMed Score 19.62
PubMed score by year
PubTator Score 17.97
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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