You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CEP192
Centrosomal protein of 192 kDa

Protein Summary
Description
Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000506447
  • ENSP00000427550
  • ENSG00000101639

Symbol
  • KIAA1569
  • PPP1R62
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
tissue
0.69
virus perturbation
0.68
cellular component
0.64
cell line
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.62   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.62   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
SIL1
Tbio
Novelty:  0.00848561
p_int:  0.999999867
p_ni:  1.32e-7
p_wrong:  2e-9
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.999999753
p_ni:  1.64e-7
p_wrong:  8.3e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
DCTPP1
Tchem
Family:  Enzyme
Novelty:  0.05521767
p_int:  0.999994796
p_ni:  0.000005195
p_wrong:  9e-9
Score:  0.517
Data Source:  BioPlex,STRINGDB
FEZ1
Tbio
Novelty:  0.02695814
p_int:  0.999633319
p_ni:  0.000366645
p_wrong:  3.6e-8
Score:  0.546
Data Source:  BioPlex,STRINGDB
HOMER3
Tbio
Novelty:  0.04408998
p_int:  0.9993818
p_ni:  0.000618148
p_wrong:  5.1e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
p_int:  0.998901687
p_ni:  0.001096783
p_wrong:  0.00000153
Data Source:  BioPlex
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.991122315
p_ni:  0.002196976
p_wrong:  0.006680709
Score:  0.264
Data Source:  BioPlex,STRINGDB
PLK4
Tchem
Family:  Kinase
Novelty:  0.00265851
Score:  0.997
Data Source:  STRINGDB
NEDD1
Tbio
Novelty:  0.03077131
Score:  0.987
Data Source:  STRINGDB
CEP152
Tbio
Novelty:  0.02129779
Score:  0.974
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
1
3
75
self reported educational attainment
3
2
2
5.8
55.8
intelligence
5
3
2
5.5
42.2
C-reactive protein measurement
1
1
1
38.2
heel bone mineral density
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
75
self reported educational attainment
2
5.8
55.8
intelligence
2
5.5
42.2
C-reactive protein measurement
1
38.2
heel bone mineral density
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 192
VGNC:5149
468602
Mouse
MGI:1918049
70799
Dog
centrosomal protein 192 [Source:HGNC Symbol;Acc:HGNC:25515]
Horse
centrosomal protein 192
VGNC:50928
100057580
Cow
centrosomal protein 192
VGNC:27199
104975778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 192
Mouse
Dog
centrosomal protein 192 [Source:HGNC Symbol;Acc:HGNC:25515]
Horse
centrosomal protein 192
Cow
centrosomal protein 192
Publication Statistics
PubMed Score 19.62
PubMed score by year
PubTator Score 17.97
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title