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Tbio
NUP210
Nuclear pore membrane glycoprotein 210

Protein Classes
Protein Summary
Description
Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254508
  • ENSP00000254508
  • ENSG00000132182

Symbol
  • KIAA0906
  • GP210
  • POM210
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.96
virus perturbation
0.83
transcription factor binding site profile
0.82
pathway
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.96   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.96   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
4
4
66.3
red blood cell distribution width
1
1
1
38.8
mathematical ability
2
2
2
34.9
body mass index
1
1
1
14.2
corneal topography
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
4
66.3
red blood cell distribution width
1
38.8
mathematical ability
2
34.9
body mass index
1
14.2
corneal topography
1
11.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 210
VGNC:2491
460189
Macaque
nucleoporin 210
693669
Mouse
MGI:1859555
54563
Rat
RGD:69339
58958
Dog
nucleoporin 210
VGNC:44050
484632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 210
Macaque
nucleoporin 210
Mouse
Rat
Dog
nucleoporin 210
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TEM1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (72)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (190)
1 – 10 of 190
NOCT
Tbio
Novelty:  0.01696096
p_int:  0.801279992
p_ni:  0.198720008
Score:  0.237
Data Source:  BioPlex,STRINGDB
RHOBTB3
Tbio
Novelty:  0.09149494
p_int:  0.794846117
p_ni:  0.205153883
Score:  0.345
Data Source:  BioPlex,STRINGDB
NUP107
Tbio
Novelty:  0.01994155
Score:  0.993
Data Source:  STRINGDB
NUP153
Tbio
Novelty:  0.00696568
Score:  0.992
Data Source:  STRINGDB
NUP155
Tbio
Novelty:  0.03884486
Score:  0.984
Data Source:  STRINGDB
NUP205
Tbio
Novelty:  0.06778513
Score:  0.983
Data Source:  STRINGDB
SP100
Tbio
Family:  TF; Epigenetic
Novelty:  0.00201806
Score:  0.983
Data Source:  STRINGDB
NUP214
Tbio
Novelty:  0.00924336
Score:  0.983
Data Source:  STRINGDB
NUP35
Tbio
Novelty:  0.0355102
Score:  0.982
Data Source:  STRINGDB
NUP93
Tbio
Novelty:  0.0248311
Score:  0.982
Data Source:  STRINGDB
Publication Statistics
PubMed Score  138.96

PubMed score by year
PubTator Score  81.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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