You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRPC4AP
Short transient receptor potential channel 4-associated protein

Protein Summary
Description
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252015
  • ENSP00000252015
  • ENSG00000100991
  • ENST00000451813
  • ENSP00000400614

Symbol
  • C20orf188
  • TRRP4AP
  • TRUSS
  • TRRP4AP
  • PPP1R158
  • C20orf188
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor binding site profile
0.84
histone modification site profile
0.75
small molecule perturbation
0.68
tissue sample
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.43   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.43   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
SMCHD1
Tbio
Novelty:  0.01383021
p_int:  0.999999082
p_ni:  9.18e-7
Score:  0.232
Data Source:  BioPlex,STRINGDB
CCDC6
Tbio
Novelty:  0.00702098
p_int:  0.999999029
p_ni:  9.71e-7
Data Source:  BioPlex
CUL4B
Tbio
Novelty:  0.0133075
p_int:  0.999802604
p_ni:  0.000197396
Score:  0.92
Data Source:  BioPlex,STRINGDB
CUL4A
Tchem
Novelty:  0.00917788
p_int:  0.999678712
p_ni:  0.000321288
Score:  0.939
Data Source:  BioPlex,STRINGDB
SDR9C7
Tbio
Family:  Enzyme
Novelty:  0.01618496
p_int:  0.999628252
p_ni:  0.000371747
p_wrong:  1e-9
Data Source:  BioPlex
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
p_int:  0.999589143
p_ni:  0.000385495
p_wrong:  0.000025362
Score:  0.195
Data Source:  BioPlex,STRINGDB
DDB1
Tbio
Novelty:  0.00345896
p_int:  0.999045887
p_ni:  0.000954113
Score:  0.949
Data Source:  BioPlex,STRINGDB
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.999015508
p_ni:  0.000984459
p_wrong:  3.2e-8
Data Source:  BioPlex
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.998871632
p_ni:  0.001128368
Data Source:  BioPlex
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.997793608
p_ni:  0.002204137
p_wrong:  0.000002255
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
5
2
1.1
94.7
factor VII measurement
1
2
2
93.6
glomerular filtration rate
4
3
3
8.6
92.7
appendicular lean mass
3
3
7
92
protein C measurement
2
2
2
91.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
94.7
factor VII measurement
2
93.6
glomerular filtration rate
3
8.6
92.7
appendicular lean mass
7
92
protein C measurement
2
91.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 4 associated protein
VGNC:10018
458196
Macaque
transient receptor potential cation channel subfamily C member 4 associated protein
712164
Mouse
MGI:1930751
56407
Rat
RGD:1309914
362247
Dog
transient receptor potential cation channel subfamily C member 4 associated protein
VGNC:47869
477207
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 4 associated protein
Macaque
transient receptor potential cation channel subfamily C member 4 associated protein
Mouse
Rat
Dog
transient receptor potential cation channel subfamily C member 4 associated protein
Publication Statistics
PubMed Score 44.43
PubMed score by year
PubTator Score 4.28
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title