DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.79 | ||
protein domain | 0.73 | ||
transcription factor binding site profile | 0.72 | ||
transcription factor | 0.68 | ||
molecular function | 0.67 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | PKMTs methylate histone lysines | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
PKMTs methylate histone lysines | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hematocrit | 6 | 6 | 6 | 98 | |||||
hemoglobin measurement | 5 | 5 | 5 | 97.7 | |||||
BMI-adjusted hip circumference | 3 | 13 | 15 | 96.3 | |||||
body height | 5 | 5 | 5 | 94 | |||||
red blood cell density measurement | 2 | 2 | 2 | 92.9 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hematocrit | 6 | 98 | |||||
hemoglobin measurement | 5 | 97.7 | |||||
BMI-adjusted hip circumference | 15 | 96.3 | |||||
body height | 5 | 94 | |||||
red blood cell density measurement | 2 | 92.9 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | DOT1 like histone lysine methyltransferase | VGNC:7478 | 455566 | |||||
Macaque | DOT1 like histone lysine methyltransferase | 710033 | ||||||
Mouse | MGI:2143886 | 208266 | ||||||
Rat | RGD:1306644 | 362831 | ||||||
Dog | DOT1 like histone lysine methyltransferase | VGNC:54298 | 485073 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | DOT1 like histone lysine methyltransferase | |||||
Macaque | DOT1 like histone lysine methyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | DOT1 like histone lysine methyltransferase | |||||
PMID | Year | Title |
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