DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Protein Summary
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
- ENST00000398665
- ENSP00000381657
- ENSG00000104885
- KIAA1814
- KMT4
- DOT1
- KMT4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.79 | ||
protein domain | 0.73 | ||
transcription factor binding site profile | 0.72 | ||
transcription factor | 0.68 | ||
molecular function | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 306.16 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 441 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 306.16 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 441 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 67
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (67)
Protein-Protein Interactions (209)
MLLT6
Family: Epigenetic
Novelty: 0.03728427
p_int: 0.999999855
p_ni: 1.45e-7
Score: 0.849
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (3)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | PKMTs methylate histone lysines | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
PKMTs methylate histone lysines | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (5)
Components (5)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hematocrit | 6 | 6 | 6 | 98 | |||||
hemoglobin measurement | 5 | 5 | 5 | 97.7 | |||||
BMI-adjusted hip circumference | 3 | 13 | 15 | 96.3 | |||||
body height | 5 | 5 | 5 | 94 | |||||
red blood cell density measurement | 2 | 2 | 2 | 92.9 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hematocrit | 6 | 98 | |||||
hemoglobin measurement | 5 | 97.7 | |||||
BMI-adjusted hip circumference | 15 | 96.3 | |||||
body height | 5 | 94 | |||||
red blood cell density measurement | 2 | 92.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DOT1 like histone lysine methyltransferase | VGNC:7478 | 455566 | |||||
Macaque | DOT1 like histone lysine methyltransferase | 710033 | ||||||
Mouse | MGI:2143886 | 208266 | ||||||
Rat | RGD:1306644 | 362831 | ||||||
Dog | DOT1 like histone lysine methyltransferase | VGNC:54298 | 485073 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DOT1 like histone lysine methyltransferase | |||||
Macaque | DOT1 like histone lysine methyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | DOT1 like histone lysine methyltransferase | |||||
Publication Statistics
PubMed Score 306.16
PubMed score by year
PubTator Score 139.23
PubTator score by year
Related Publications
Text Mined References (76)
GeneRif Annotations (58)
Items per page:
0 of 0
PMID | Year | Title |
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