DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Protein Classes
Protein Summary
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
- ENST00000398665
- ENSP00000381657
- ENSG00000104885
- KIAA1814
- KMT4
- DOT1
- KMT4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.79 | ||
protein domain | 0.73 | ||
transcription factor binding site profile | 0.72 | ||
transcription factor | 0.68 | ||
molecular function | 0.67 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 296.85 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 441 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 296.85 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 441 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 39
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (39)
1 – 10 of 39
GWAS Traits (16)
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1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 3 | 2 | 3 | 95.5 | |||||
body height | 3 | 3 | 3 | 94.2 | |||||
heel bone mineral density | 3 | 2 | 4 | 91.1 | |||||
hemoglobin measurement | 3 | 3 | 3 | 91 | |||||
waist-hip ratio | 2 | 1 | 2 | 87.7 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 3 | 95.5 | |||||
body height | 3 | 94.2 | |||||
heel bone mineral density | 4 | 91.1 | |||||
hemoglobin measurement | 3 | 91 | |||||
waist-hip ratio | 2 | 87.7 | |||||
Orthologs (13)
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Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DOT1 like histone lysine methyltransferase | VGNC:7478 | 455566 | |||||
Macaque | DOT1 like histone lysine methyltransferase | 710033 | ||||||
Mouse | MGI:2143886 | 208266 | ||||||
Rat | RGD:1306644 | 362831 | ||||||
Dog | DOT1 like histone lysine methyltransferase | VGNC:54298 | 485073 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DOT1 like histone lysine methyltransferase | |||||
Macaque | DOT1 like histone lysine methyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | DOT1 like histone lysine methyltransferase | |||||
Protein Structure (29 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 29
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (6)
Reactome (3)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | PKMTs methylate histone lysines | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
PKMTs methylate histone lysines | ||||
Gene Ontology Terms (18)
Functions (5)
Components (5)
Processes (8)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (209)
1 – 10 of 209
MLLT6
Family: Epigenetic
Novelty: 0.03728427
p_int: 0.999999855
p_ni: 1.45e-7
Score: 0.849
Data Source: BioPlex,STRINGDB
DAXX
Novelty: 0.00348585
p_int: 0.999964797
p_ni: 0.000035203
Data Source: BioPlex
MLLT10
Family: Epigenetic
Novelty: 0.00590548
Score: 0.917
Data Source: STRINGDB
MLLT3
Novelty: 0.00361056
Score: 0.916
Data Source: STRINGDB
SETD2
Family: Epigenetic
Novelty: 0.00178899
Score: 0.908
Data Source: STRINGDB
SETD1A
Family: Epigenetic
Novelty: 0.00248544
Score: 0.904
Data Source: STRINGDB
TP53BP1
Family: Epigenetic
Novelty: 0.00131256
Score: 0.9
Data Source: STRINGDB
RNF20
Family: Enzyme
Novelty: 0.01238827
Score: 0.872
Data Source: STRINGDB
SIRT1
Family: Epigenetic
Novelty: 0.00022265
Score: 0.868
Data Source: STRINGDB
CAMKMT
Family: Enzyme
Novelty: 0.00382649
Score: 0.851
Data Source: STRINGDB
Publication Statistics
PubMed Score 296.85
PubMed score by year
PubTator Score 139.23
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait