DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Protein Summary
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
- ENST00000398665
- ENSP00000381657
- ENSG00000104885
- KIAA1814
- KMT4
- DOT1
- KMT4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.79 | ||
protein domain | 0.73 | ||
transcription factor binding site profile | 0.72 | ||
transcription factor | 0.68 | ||
molecular function | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 374.21 (req: < 5)
Gene RIFs: 100 (req: <= 3)
Antibodies: 441 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 374.21 (req: >= 5)
Gene RIFs: 100 (req: > 3)
Antibodies: 441 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 68
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0