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Tchem
DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

Protein Summary
Description
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398665
  • ENSP00000381657
  • ENSG00000104885

Symbol
  • KIAA1814
  • KMT4
  • DOT1
  • KMT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.79
protein domain
0.73
transcription factor binding site profile
0.72
transcription factor
0.68
molecular function
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.85   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.85   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (39)
1 – 10 of 39
CHEMBL418052
chemical structure image
CHEMBL2349526
chemical structure image
CHEMBL2171001
chemical structure image
CHEMBL2169919
chemical structure image
CHEMBL2170999
chemical structure image
CHEMBL2171169
chemical structure image
CHEMBL2170989
chemical structure image
CHEMBL2170992
chemical structure image
CHEMBL2171174
chemical structure image
CHEMBL2170996
chemical structure image
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
2
3
95.5
body height
3
3
3
94.2
heel bone mineral density
3
2
4
91.1
hemoglobin measurement
3
3
3
91
waist-hip ratio
2
1
2
87.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
95.5
body height
3
94.2
heel bone mineral density
4
91.1
hemoglobin measurement
3
91
waist-hip ratio
2
87.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DOT1 like histone lysine methyltransferase
VGNC:7478
455566
Macaque
DOT1 like histone lysine methyltransferase
710033
Mouse
MGI:2143886
208266
Rat
RGD:1306644
362831
Dog
DOT1 like histone lysine methyltransferase
VGNC:54298
485073
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DOT1 like histone lysine methyltransferase
Macaque
DOT1 like histone lysine methyltransferase
Mouse
Rat
Dog
DOT1 like histone lysine methyltransferase
Protein Structure (29 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TEK3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 29
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (209)
1 – 10 of 209
MLLT6
Tdark
Family: Epigenetic
Novelty: 0.03728427
p_int: 0.999999855
p_ni: 1.45e-7
Score: 0.849
Data Source: BioPlex,STRINGDB
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.999964797
p_ni: 0.000035203
Data Source: BioPlex
MLLT10
Tbio
Family: Epigenetic
Novelty: 0.00590548
Score: 0.917
Data Source: STRINGDB
MLLT3
Tbio
Novelty: 0.00361056
Score: 0.916
Data Source: STRINGDB
SETD2
Tchem
Family: Epigenetic
Novelty: 0.00178899
Score: 0.908
Data Source: STRINGDB
SETD1A
Tbio
Family: Epigenetic
Novelty: 0.00248544
Score: 0.904
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.9
Data Source: STRINGDB
RNF20
Tbio
Family: Enzyme
Novelty: 0.01238827
Score: 0.872
Data Source: STRINGDB
SIRT1
Tchem
Family: Epigenetic
Novelty: 0.00022265
Score: 0.868
Data Source: STRINGDB
CAMKMT
Tbio
Family: Enzyme
Novelty: 0.00382649
Score: 0.851
Data Source: STRINGDB
Publication Statistics
PubMed Score  296.85

PubMed score by year
PubTator Score  139.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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