DENND1A
DENN domain-containing protein 1A
Protein Summary
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
- ENST00000373618
- ENSP00000362720
- ENSG00000119522
- ENST00000373620
- ENSP00000362722
- ENST00000373624
- ENSP00000362727
- FAM31A
- KIAA1608
- FAM31A
- KIAA1608
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.8 | ||
phenotype | 0.79 | ||
transcription factor | 0.79 | ||
drug perturbation | 0.71 | ||
cellular component | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.4 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 128 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.4 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 128 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (44)
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Membrane Trafficking | ||||
Reactome | RAB GEFs exchange GTP for GDP on RABs | ||||
Reactome | Rab regulation of trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Membrane Trafficking | ||||
RAB GEFs exchange GTP for GDP on RABs | ||||
Rab regulation of trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (5)
Components (9)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 3 | 1 | 1.4 | 86.8 | |||||
hair color | 1 | 1 | 0 | 1.1 | 85.7 | ||||
risk-taking behaviour | 3 | 3 | 3 | 1 | 79.4 | ||||
body mass index | 4 | 4 | 5 | 75.6 | |||||
self reported educational attainment | 1 | 2 | 2 | 72.4 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.4 | 86.8 | |||||
hair color | 0 | 1.1 | 85.7 | ||||
risk-taking behaviour | 3 | 1 | 79.4 | ||||
body mass index | 5 | 75.6 | |||||
self reported educational attainment | 2 | 72.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DENN domain containing 1A | VGNC:4672 | 473055 | |||||
Macaque | DENN domain containing 1A | 698028 | ||||||
Mouse | MGI:2442794 | 227801 | ||||||
Rat | RGD:1307927 | 311913 | ||||||
Dog | DENN domain containing 1A | VGNC:39884 | 609706 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DENN domain containing 1A | |||||
Macaque | DENN domain containing 1A | |||||
Mouse | ||||||
Rat | ||||||
Dog | DENN domain containing 1A | |||||
Publication Statistics
PubMed Score 27.40
PubMed score by year
PubTator Score 19.06
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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