Tbio DENND1A DENN domain-containing protein 1A

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q8TEH3
• A8MZA3
• B1AM80
• B7Z3C8
• B7Z669
• D3PFD3
• Q05C88
• Q5VWF0
• Q6PJZ5
• Q8IVD6
• Q9H796

Gene Name

• DENND1A

Ensembl ID

• ENST00000373618
• ENSP00000362720
• ENSG00000119522
• ENST00000373620
• ENSP00000362722
• ENST00000373624
• ENSP00000362727

Symbol

• FAM31A
• KIAA1608
• FAM31A
• KIAA1608

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.8
phenotype	0.79
transcription factor	0.79
drug perturbation	0.71
cellular component	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.46   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.46   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0