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Tbio
DENND1A
DENN domain-containing protein 1A

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373618
  • ENSP00000362720
  • ENSG00000119522
  • ENST00000373620
  • ENSP00000362722
  • ENST00000373624
  • ENSP00000362727

Symbol
  • FAM31A
  • KIAA1608
  • FAM31A
  • KIAA1608
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
phenotype
0.79
transcription factor
0.79
drug perturbation
0.71
cellular component
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.4   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.4   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
RAB35
Tbio
Family:  Enzyme
Novelty:  0.01514601
Score:  0.99
Data Source:  Reactome,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.938
Data Source:  Reactome,STRINGDB
DENND1B
Tbio
Novelty:  0.07206972
Score:  0.906
Data Source:  STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.902
Data Source:  STRINGDB
GDI2
Tbio
Novelty:  0.02861013
Score:  0.9
Data Source:  Reactome,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
Score:  0.9
Data Source:  Reactome,STRINGDB
GDI1
Tbio
Novelty:  0.01710945
Score:  0.9
Data Source:  Reactome,STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
Score:  0.9
Data Source:  Reactome,STRINGDB
AKT3
Tchem
Family:  Kinase
Novelty:  0.00308931
Score:  0.9
Data Source:  STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
Score:  0.9
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
1
1.4
86.8
hair color
1
1
0
1.1
85.7
risk-taking behaviour
3
3
3
1
79.4
body mass index
4
4
5
75.6
self reported educational attainment
1
2
2
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.4
86.8
hair color
0
1.1
85.7
risk-taking behaviour
3
1
79.4
body mass index
5
75.6
self reported educational attainment
2
72.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DENN domain containing 1A
VGNC:4672
473055
Macaque
DENN domain containing 1A
698028
Mouse
MGI:2442794
227801
Rat
RGD:1307927
311913
Dog
DENN domain containing 1A
VGNC:39884
609706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DENN domain containing 1A
Macaque
DENN domain containing 1A
Mouse
Rat
Dog
DENN domain containing 1A
Publication Statistics
PubMed Score 27.40
PubMed score by year
PubTator Score 19.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title