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Tbio
GPX8
Probable glutathione peroxidase 8

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000503787
  • ENSP00000423822
  • ENSG00000164294

Symbol
  • GPx-8
  • UNQ847
  • EPLA847
  • GSHPx-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
virus perturbation
0.85
small molecule perturbation
0.79
kinase perturbation
0.66
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (94)
1 – 10 of 94
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.951210963
p_ni:  0.048788971
p_wrong:  6.5e-8
Score:  0.432
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.809909478
p_ni:  0.190090522
Data Source:  BioPlex
CHST6
Tbio
Family:  Enzyme
Novelty:  0.01917947
p_int:  0.790986989
p_ni:  0.20901276
p_wrong:  2.51e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.788810055
p_ni:  0.211189945
Score:  0.152
Data Source:  BioPlex,STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
Score:  0.973
Data Source:  STRINGDB
SOD2
Tbio
Family:  Enzyme
Novelty:  0.00084288
Score:  0.971
Data Source:  STRINGDB
SOD3
Tbio
Family:  Enzyme
Novelty:  0.0015758
Score:  0.957
Data Source:  STRINGDB
ERO1A
Tbio
Novelty:  0.01022914
Score:  0.952
Data Source:  Reactome,STRINGDB
GSS
Tbio
Family:  Enzyme
Novelty:  0.03002278
Score:  0.945
Data Source:  STRINGDB
P4HB
Tchem
Family:  Enzyme
Novelty:  0.00107905
Score:  0.941
Data Source:  Reactome,STRINGDB
Pathways (8)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glutathione peroxidase 8 (putative)
705965
Mouse
MGI:1916840
69590
Rat
RGD:1307506
294744
Dog
glutathione peroxidase 8 (putative)
478059
Horse
glutathione peroxidase 8 (putative)
100052064
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glutathione peroxidase 8 (putative)
Mouse
Rat
Dog
glutathione peroxidase 8 (putative)
Horse
glutathione peroxidase 8 (putative)
Publication Statistics
PubMed Score 40.38
PubMed score by year
PubTator Score 6.18
PubTator score by year