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Tbio
UTP15
U3 small nucleolar RNA-associated protein 15 homolog

Protein Summary
Description
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296792
  • ENSP00000296792
  • ENSG00000164338
  • ENST00000508491
  • ENSP00000424609
  • ENST00000543251
  • ENSP00000440796

Symbol
  • NET21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
kinase perturbation
0.84
protein domain
0.73
drug perturbation
0.71
cellular component
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.45   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.45   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (340)
UTP4
Tbio
Novelty:  0.06989008
p_int:  0.999999504
p_ni:  4.96e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
NOL7
Tbio
Novelty:  0.24085052
p_int:  0.999978002
p_ni:  0.000021998
Score:  0.676
Data Source:  BioPlex,STRINGDB
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999356226
p_ni:  0.000643774
Data Source:  BioPlex
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.996204273
p_ni:  0.003795727
Score:  0.905
Data Source:  BioPlex,STRINGDB
C1D
Tbio
Novelty:  0.00997109
p_int:  0.994262767
p_ni:  0.005737233
Score:  0.964
Data Source:  BioPlex,STRINGDB
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
p_int:  0.989983587
p_ni:  0.010016413
Score:  0.183
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.964427252
p_ni:  0.035572747
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
TBC1D15
Tbio
Novelty:  0.11296513
p_int:  0.961777992
p_ni:  0.038221932
p_wrong:  7.6e-8
Score:  0.203
Data Source:  BioPlex,STRINGDB
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.902728611
p_ni:  0.097271389
Data Source:  BioPlex
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.893582365
p_ni:  0.106417635
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
70.4
reticulocyte count
2
1
2
51.7
reticulocyte measurement
2
1
2
42.3
high density lipoprotein cholesterol measurement
1
1
1
31.4
apolipoprotein A 1 measurement
2
2
2
30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
70.4
reticulocyte count
2
51.7
reticulocyte measurement
2
42.3
high density lipoprotein cholesterol measurement
1
31.4
apolipoprotein A 1 measurement
2
30
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UTP15, small subunit processome component
VGNC:7194
740321
Macaque
UTP15, small subunit processome component
703573
Mouse
MGI:2145443
105372
Rat
RGD:1310992
310019
Dog
UTP15, small subunit processome component
VGNC:48209
478098
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UTP15, small subunit processome component
Macaque
UTP15, small subunit processome component
Mouse
Rat
Dog
UTP15, small subunit processome component
Publication Statistics
PubMed Score 14.45
PubMed score by year
PubTator Score 5.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title