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Tbio
RNF128
E3 ubiquitin-protein ligase RNF128

Protein Summary
Description
E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255499
  • ENSP00000255499
  • ENSG00000133135
  • ENST00000324342
  • ENSP00000316127

Symbol
  • GRAIL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
transcription factor perturbation
0.84
phenotype
0.78
gene perturbation
0.75
small molecule perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.85   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.85   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
5
0
2.2
92.8
glomerular filtration rate
1
1
0
9.3
72.9
creatinine measurement
1
1
1
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.2
92.8
glomerular filtration rate
0
9.3
72.9
creatinine measurement
1
72.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 128, E3 ubiquitin protein ligase
700890
Mouse
MGI:1914139
66889
Rat
RGD:1566282
315911
Dog
ring finger protein 128, E3 ubiquitin protein ligase
VGNC:45628
492051
Horse
ring finger protein 128, E3 ubiquitin protein ligase
VGNC:22432
100054821
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 128, E3 ubiquitin protein ligase
Mouse
Rat
Dog
ring finger protein 128, E3 ubiquitin protein ligase
Horse
ring finger protein 128, E3 ubiquitin protein ligase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TEB7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Ovarian tumor domain proteases
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Ovarian tumor domain proteases
Post-translational protein modification
Ub-specific processing proteases
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
HFE
Tbio
Novelty:  0.00042077
p_int:  0.999631169
p_ni:  0.000053894
p_wrong:  0.000314937
Data Source:  BioPlex
USP8
Tchem
Family:  Enzyme
Novelty:  0.0105645
Score:  0.98
Data Source:  Reactome,STRINGDB
OTUB1
Tbio
Family:  Enzyme
Novelty:  0.00536726
Score:  0.976
Data Source:  Reactome,STRINGDB
OTUB2
Tbio
Family:  Enzyme
Novelty:  0.00821431
Score:  0.957
Data Source:  STRINGDB
STX5
Tbio
Novelty:  0.00964918
Score:  0.643
Data Source:  STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.608
Data Source:  STRINGDB
CD151
Tbio
Novelty:  0.00295527
Score:  0.592
Data Source:  STRINGDB
TMEM37
Tbio
Family:  IC
Novelty:  0.00167645
Score:  0.581
Data Source:  STRINGDB
OSBPL2
Tbio
Novelty:  0.03946704
Score:  0.551
Data Source:  STRINGDB
USP38
Tbio
Family:  Enzyme
Novelty:  0.10350208
Score:  0.539
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.85

PubMed score by year
PubTator Score  53.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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