DCAF11
DDB1- and CUL4-associated factor 11
Protein Summary
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
- ENST00000396936
- ENSP00000380142
- ENSG00000100897
- ENST00000396941
- ENSP00000380146
- ENST00000446197
- ENSP00000415556
- ENST00000559115
- ENSP00000452898
- ENST00000642239
- ENSP00000494282
- ENSG00000284796
- ENST00000644566
- ENSP00000493711
- ENST00000646524
- ENSP00000495415
- ENST00000646568
- ENSP00000495416
- WDR23
- GL014
- WDR23
- PRO2389
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.93 | ||
disease perturbation | 0.9 | ||
kinase perturbation | 0.81 | ||
histone modification site profile | 0.77 | ||
transcription factor | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.52 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 76 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.52 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 76 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0