Tbio DTD1 D-aminoacyl-tRNA deacylase 1

Protein Summary

Description

Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q8TEA8
• A8K5X5
• D3DW37
• Q496D1
• Q5W184
• Q8WXU8
• Q9BW67
• Q9H464
• Q9H474
• DTD

Gene Name

• DTD1

Ensembl ID

• ENST00000377452
• ENSP00000366672
• ENSG00000125821

Symbol

• C20orf88
• DUEB
• HARS2
• DTD
• DUEB
• DUE-B
• HARS2
• pqn-68
• C20orf88

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.68
kinase perturbation	0.66
transcription factor binding site profile	0.66
histone modification site profile	0.65
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Hydrolase / Esterase / D-aminoacyl-trna Deacylase 1

DTO Classes

Protein / Enzyme / Hydrolase / Esterase / D-aminoacyl-trna Deacylase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.47   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.47   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0