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Tbio
TBCK
TBC domain-containing protein kinase-like protein

Protein Summary
Description
Involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:27040691, PubMed:23977024). Involved in the regulation of cell proliferation and growth (PubMed:23977024, PubMed:24576458). Involved in the control of actin-cytoskeleton organization (PubMed:23977024). This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273980
  • ENSP00000273980
  • ENSG00000145348
  • ENST00000361687
  • ENSP00000355338
  • ENST00000394706
  • ENSP00000378196
  • ENST00000394708
  • ENSP00000378198
  • ENST00000432496
  • ENSP00000405847

Symbol
  • TBCKL
  • TBCKL
  • IHPRF3
  • HSPC302
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
molecular function
0.88
kinase perturbation
0.84
tissue sample
0.7
transcription factor binding site profile
0.67


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.41   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.41   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
62.5
Agents acting on the renin-angiotensin system use measurement
1
1
1
52.7
Diuretic use measurement
1
1
1
36.9
Calcium channel blocker use measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
62.5
Agents acting on the renin-angiotensin system use measurement
1
52.7
Diuretic use measurement
1
36.9
Calcium channel blocker use measurement
1
21.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain containing kinase
VGNC:733
471266
Macaque
TBC1 domain containing kinase
694605
Mouse
MGI:2445052
271981
Rat
RGD:1307816
295446
Dog
TBC1 domain containing kinase
VGNC:47159
487892
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain containing kinase
Macaque
TBC1 domain containing kinase
Mouse
Rat
Dog
TBC1 domain containing kinase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TEA7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (27)
1 – 10 of 27
IL6R
Tclin
Novelty:  0.00185005
p_int:  0.999999977
p_ni:  2e-8
p_wrong:  2e-9
Score:  0.282
Data Source:  BioPlex,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999999905
p_ni:  1.1e-8
p_wrong:  8.4e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
C12orf4
Tdark
Novelty:  0.35695485
Score:  0.655
Data Source:  STRINGDB
MYO1H
Tdark
Novelty:  0.13056549
Score:  0.604
Data Source:  STRINGDB
ARAP2
Tbio
Novelty:  0.04566051
Score:  0.549
Data Source:  STRINGDB
FRYL
Tdark
Novelty:  0.13893531
Score:  0.518
Data Source:  STRINGDB
TBC1D19
Tdark
Novelty:  1.33062726
Score:  0.517
Data Source:  STRINGDB
XRRA1
Tdark
Novelty:  0.80740801
Score:  0.515
Data Source:  STRINGDB
SBK3
Tchem
Family:  Kinase
Novelty:  1.61347518
Score:  0.511
Data Source:  STRINGDB
GALNT17
Tbio
Family:  Enzyme
Novelty:  0.13553627
Score:  0.506
Data Source:  STRINGDB
Publication Statistics
PubMed Score  15.41

PubMed score by year
PubTator Score  6.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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