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Tdark
SH3TC1
SH3 domain and tetratricopeptide repeat-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245105
  • ENSP00000245105
  • ENSG00000125089
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.68
tissue sample
0.67
gene perturbation
0.63
transcription factor binding site profile
0.61
cell type or tissue
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.44   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.44   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
68.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain and tetratricopeptide repeats 1
VGNC:684
461113
Macaque
SH3 domain and tetratricopeptide repeats 1
722649
Mouse
MGI:2678949
231147
Rat
RGD:1305610
305441
Dog
SH3 domain and tetratricopeptide repeats 1
VGNC:46135
488788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain and tetratricopeptide repeats 1
Macaque
SH3 domain and tetratricopeptide repeats 1
Mouse
Rat
Dog
SH3 domain and tetratricopeptide repeats 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TE82-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (28)
1 – 10 of 28
AFAP1
Tbio
Novelty: 0.00859495
Score: 0.71
Data Source: STRINGDB
ABLIM2
Tdark
Novelty: 0.23629309
Score: 0.687
Data Source: STRINGDB
SORCS2
Tbio
Novelty: 0.0590681
Score: 0.597
Data Source: STRINGDB
PSAPL1
Tdark
Novelty: 0.82322044
Score: 0.577
Data Source: STRINGDB
CPAMD8
Tbio
Novelty: 0.05558484
Score: 0.552
Data Source: STRINGDB
STARD8
Tbio
Novelty: 0.03759193
Score: 0.548
Data Source: STRINGDB
GUCY1A2
Tclin
Family: Enzyme
Novelty: 0.05335767
Score: 0.509
Data Source: STRINGDB
AKIRIN2
Tbio
Novelty: 0.04603317
Score: 0.498
Data Source: STRINGDB
DCAF7
Tbio
Novelty: 0.02609518
Score: 0.498
Data Source: STRINGDB
CCDC38
Tdark
Novelty: 0.55483644
Score: 0.497
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.44

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer