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Tbio
DNAH5
Dynein heavy chain 5, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265104
  • ENSP00000265104
  • ENSG00000039139

Symbol
  • DNAHC5
  • HL1
  • KIAA1603
  • HL1
  • PCD
  • CILD3
  • KTGNR
  • DNAHC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.93
trait
0.86
cellular component
0.73
protein complex
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.71   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.71   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
1
1
0
2.7
36.5
response to radiation
1
1
0
2.7
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
2.7
36.5
response to radiation
0
2.7
36.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal heavy chain 5
VGNC:8617
461726
Macaque
dynein axonemal heavy chain 5
717339
Mouse
MGI:107718
110082
Rat
RGD:1560828
294854
Dog
dynein axonemal heavy chain 5
VGNC:40016
606983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal heavy chain 5
Macaque
dynein axonemal heavy chain 5
Mouse
Rat
Dog
dynein axonemal heavy chain 5
Protein Structure (0 Structures, 18 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (112)
1 – 10 of 112
DNAI2
Tbio
Novelty: 0.02801096
Score: 0.98
Data Source: STRINGDB
DNAL1
Tbio
Novelty: 0.00168166
Score: 0.973
Data Source: STRINGDB
DNAI1
Tbio
Novelty: 0.01021193
Score: 0.965
Data Source: STRINGDB
DNALI1
Tbio
Novelty: 0.13865981
Score: 0.957
Data Source: STRINGDB
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.942
Data Source: STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.938
Data Source: STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
Score: 0.936
Data Source: STRINGDB
CLIP1
Tbio
Novelty: 0.00399891
Score: 0.935
Data Source: STRINGDB
CCDC114
Tbio
Novelty: 0.12534741
Score: 0.932
Data Source: STRINGDB
DNAH6
Tdark
Novelty: 0.18343511
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  64.71

PubMed score by year
PubTator Score  37.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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