Tbio DNAH5 Dynein heavy chain 5, axonemal

Protein Summary

Description

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q8TE73
• Q92860
• Q96L74
• Q9H5S7
• Q9HCG9

Gene Name

• DNAH5

Ensembl ID

• ENST00000265104
• ENSP00000265104
• ENSG00000039139

Symbol

• DNAHC5
• HL1
• KIAA1603
• HL1
• PCD
• CILD3
• KTGNR
• DNAHC5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.93
trait	0.86
cellular component	0.73
protein complex	0.69

Protein Classes

PANTHER Classes

Protein / Hydrolase / Dynein Heavy Chain 5, Axonemal

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Dynein Heavy Chain 5, Axonemal

DTO Classes

Protein / Enzyme / Hydrolase / Dynein Heavy Chain 5, Axonemal

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.83   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.83   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0