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Tbio
ADAMTS18
A disintegrin and metalloproteinase with thrombospondin motifs 18

Protein Classes
Protein Summary
Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282849
  • ENSP00000282849
  • ENSG00000140873

Symbol
  • ADAMTS21
  • KNO2
  • MMCAT
  • ADAMTS21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
microRNA
0.73
gene perturbation
0.68
cell type or tissue
0.66
tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.05   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.05   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asparaginase-induced acute pancreatitis
1
1
0
3.3
39.6
cortical surface area measurement
1
1
0
1.8
14.2
intraocular pressure measurement
3
2
3
11.6
body mass index
1
1
1
9.1
electrocardiography
1
1
5
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asparaginase-induced acute pancreatitis
0
3.3
39.6
cortical surface area measurement
0
1.8
14.2
intraocular pressure measurement
3
11.6
body mass index
1
9.1
electrocardiography
5
1.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 18
VGNC:5664
737513
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 18
712710
Mouse
MGI:2442600
208936
Rat
RGD:1560118
361412
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 18
VGNC:37596
489704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 18
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 18
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 18
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TE60-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Degradation of the extracellular matrix
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Degradation of the extracellular matrix
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (55)
1 – 10 of 55
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
p_int:  0.998358494
p_ni:  0.001641506
Score:  0.947
Data Source:  BioPlex,STRINGDB
IGKC
Tdark
p_int:  0.85576864
p_ni:  0.144231359
p_wrong:  1e-9
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.793024091
p_ni:  0.206975909
Data Source:  BioPlex
ALB
Tchem
Novelty:  0.00000616
p_int:  0.767578004
p_ni:  0.232421996
Score:  0.224
Data Source:  BioPlex,STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.928
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.927
Data Source:  STRINGDB
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.927
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.918
Data Source:  STRINGDB
ADAMTS19
Tbio
Family:  Enzyme
Novelty:  0.13082004
Score:  0.917
Data Source:  STRINGDB
ADAMTS14
Tbio
Family:  Enzyme
Novelty:  0.07885034
Score:  0.917
Data Source:  STRINGDB
Publication Statistics
PubMed Score  40.05

PubMed score by year
PubTator Score  39.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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