You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ADAMTS19
A disintegrin and metalloproteinase with thrombospondin motifs 19

Protein Classes
Protein Summary
Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000638972
  • ENSP00000491408
  • ENSG00000145808
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.81
cell type or tissue
0.76
microRNA
0.72
histone modification site profile
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.92   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.92   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
2
0
22.9
86.4
cup-to-disc ratio measurement
1
1
1
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
22.9
86.4
cup-to-disc ratio measurement
1
13.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 19
VGNC:3892
462039
Mouse
MGI:2442875
240322
Rat
RGD:1308359
361332
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 19
VGNC:37597
609332
Horse
ADAM metallopeptidase with thrombospondin type 1 motif 19
VGNC:15068
100072998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 19
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 19
Horse
ADAM metallopeptidase with thrombospondin type 1 motif 19
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TE59-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (48)
1 – 10 of 48
B3GLCT
Tbio
Family: Enzyme
Novelty: 0.02398944
Score: 0.938
Data Source: STRINGDB
THBS1
Tbio
Novelty: 0.00073905
Score: 0.93
Data Source: STRINGDB
ADAMTS20
Tbio
Family: Enzyme
Novelty: 0.0416108
Score: 0.923
Data Source: STRINGDB
ADAMTSL1
Tbio
Novelty: 0.08853044
Score: 0.92
Data Source: STRINGDB
ADAMTS13
Tbio
Family: Enzyme
Novelty: 0.0006095
Score: 0.92
Data Source: STRINGDB
ADAMTS1
Tchem
Family: Enzyme
Novelty: 0.00483758
Score: 0.919
Data Source: STRINGDB
ADAMTSL2
Tbio
Novelty: 0.05511648
Score: 0.919
Data Source: STRINGDB
ADAMTS14
Tbio
Family: Enzyme
Novelty: 0.07885034
Score: 0.919
Data Source: STRINGDB
ADAMTS8
Tbio
Family: Enzyme
Novelty: 0.04333199
Score: 0.919
Data Source: STRINGDB
ADAMTS9
Tbio
Family: Enzyme
Novelty: 0.01447959
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.92

PubMed score by year
PubTator Score  3.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer