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Tbio
ADAMTS15
A disintegrin and metalloproteinase with thrombospondin motifs 15

Protein Classes
Protein Summary
Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299164
  • ENSP00000299164
  • ENSG00000166106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.77
PubMedID
0.67
tissue sample
0.58
microRNA
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.64   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.64   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
2
3
3
91
central corneal thickness
3
2
0
6
89.9
cup-to-disc ratio measurement
4
2
5
89.6
corneal hysteresis
2
1
2
79.7
1
1
0
1.1
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
3
91
central corneal thickness
0
6
89.9
cup-to-disc ratio measurement
5
89.6
corneal hysteresis
2
79.7
0
1.1
65.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 15
VGNC:3230
466853
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 15
715608
Mouse
MGI:2449569
235130
Rat
RGD:1309770
300474
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 15
VGNC:53260
489275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 15
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 15
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 15
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TE58-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (50)
1 – 10 of 50
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.922
Data Source:  STRINGDB
ADAMTS14
Tbio
Family:  Enzyme
Novelty:  0.07885034
Score:  0.921
Data Source:  STRINGDB
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.921
Data Source:  STRINGDB
ADAMTS12
Tbio
Family:  Enzyme
Novelty:  0.03184816
Score:  0.921
Data Source:  STRINGDB
ADAMTSL2
Tbio
Novelty:  0.05511648
Score:  0.921
Data Source:  STRINGDB
ADAMTS7
Tbio
Family:  Enzyme
Novelty:  0.02347655
Score:  0.92
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.919
Data Source:  STRINGDB
ADAMTS19
Tbio
Family:  Enzyme
Novelty:  0.13082004
Score:  0.918
Data Source:  STRINGDB
ADAMTS3
Tbio
Family:  Enzyme
Novelty:  0.00578975
Score:  0.918
Data Source:  STRINGDB
ADAMTS17
Tbio
Family:  Enzyme
Novelty:  0.04568792
Score:  0.916
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.64

PubMed score by year
PubTator Score  7.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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