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Tbio
ADAMTS17
A disintegrin and metalloproteinase with thrombospondin motifs 17

Protein Summary
Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268070
  • ENSP00000268070
  • ENSG00000140470

Symbol
  • WMS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.64
cell line
0.57
PubMedID
0.57
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (50)
1 – 10 of 50
OS9
Tbio
Novelty: 0.01598375
p_int: 0.999809147
p_ni: 0.00004304
p_wrong: 0.000147813
Data Source: BioPlex
POFUT2
Tbio
Family: Enzyme
Novelty: 0.05831444
Score: 0.958
Data Source: STRINGDB
B3GLCT
Tbio
Family: Enzyme
Novelty: 0.03109
Score: 0.955
Data Source: STRINGDB
ADAMTSL4
Tbio
Novelty: 0.04959452
Score: 0.931
Data Source: STRINGDB
ADAMTSL2
Tbio
Novelty: 0.05951889
Score: 0.929
Data Source: STRINGDB
THSD4
Tbio
Novelty: 0.16828393
Score: 0.925
Data Source: STRINGDB
ADAMTSL3
Tbio
Novelty: 0.10202493
Score: 0.925
Data Source: STRINGDB
THBS1
Tbio
Novelty: 0.00083403
Score: 0.925
Data Source: STRINGDB
ADAMTSL1
Tbio
Novelty: 0.09459214
Score: 0.923
Data Source: STRINGDB
ADAMTS13
Tbio
Family: Enzyme
Novelty: 0.00073979
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.95

PubMed score by year
PubTator Score  8.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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