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Tbio
ADAMTS17
A disintegrin and metalloproteinase with thrombospondin motifs 17

Protein Summary
Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268070
  • ENSP00000268070
  • ENSG00000140470

Symbol
  • WMS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.64
cell line
0.57
PubMedID
0.57
tissue sample
0.55


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.75   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.75   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
OS9
Tbio
Novelty:  0.01490339
p_int:  0.999809147
p_ni:  0.00004304
p_wrong:  0.000147813
Data Source:  BioPlex
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.958
Data Source:  STRINGDB
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
Score:  0.955
Data Source:  STRINGDB
ADAMTSL4
Tbio
Novelty:  0.03890484
Score:  0.931
Data Source:  STRINGDB
ADAMTSL2
Tbio
Novelty:  0.05511648
Score:  0.929
Data Source:  STRINGDB
THSD4
Tbio
Novelty:  0.12898073
Score:  0.925
Data Source:  STRINGDB
ADAMTSL3
Tbio
Novelty:  0.07699522
Score:  0.925
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.925
Data Source:  STRINGDB
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.923
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
11
13
97.3
BMI-adjusted waist circumference
3
19
22
97.2
body fat distribution
3
2
11
93.1
body height
5
11
11
5.6
91.5
intraocular pressure measurement
2
1
2
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
13
97.3
BMI-adjusted waist circumference
22
97.2
body fat distribution
11
93.1
body height
11
5.6
91.5
intraocular pressure measurement
2
83.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 17
693447
Mouse
MGI:3588195
233332
Rat
RGD:1308783
293004
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 17
VGNC:37595
488708
Horse
ADAM metallopeptidase with thrombospondin type 1 motif 17
VGNC:15066
100056538
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 17
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 17
Horse
ADAM metallopeptidase with thrombospondin type 1 motif 17
Publication Statistics
PubMed Score 23.75
PubMed score by year
PubTator Score 8.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title