OTUD7A
OTU domain-containing protein 7A
Protein Summary
Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy. [provided by RefSeq, Aug 2016]
- ENST00000307050
- ENSP00000305926
- ENSG00000169918
- C15orf16
- CEZANNE2
- OTUD7
- OTUD7
- C15orf16
- C16ORF15
- CEZANNE2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.71 | ||
molecular function | 0.67 | ||
phenotype | 0.6 | ||
tissue sample | 0.59 | ||
disease | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.77 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 89 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.77 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 89 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0