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Tbio
LMX1A
LIM homeobox transcription factor 1-alpha

Protein Summary
Description
Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294816
  • ENSP00000294816
  • ENSG00000162761
  • ENST00000342310
  • ENSP00000340226
  • ENST00000367893
  • ENSP00000356868

Symbol
  • LMX1
  • LMX1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
virus perturbation
0.72
biological process
0.63
microRNA
0.63
phenotype
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.99   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.99   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
68.5
mathematical ability
2
2
2
58.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
68.5
mathematical ability
2
58.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
LIM homeobox transcription factor 1 alpha
694542
Mouse
MGI:1888519
110648
Rat
RGD:1304784
289201
Dog
LIM homeobox transcription factor 1 alpha
VGNC:42728
609061
Horse
LIM homeobox transcription factor 1 alpha
VGNC:50848
100058469
Species
Name
OMA
EggNOG
Inparanoid
Macaque
LIM homeobox transcription factor 1 alpha
Mouse
Rat
Dog
LIM homeobox transcription factor 1 alpha
Horse
LIM homeobox transcription factor 1 alpha
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TE12-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
Dopaminergic Neurogenesis
Name
Explore in Pharos
Explore in Source
Dopaminergic Neurogenesis
Dopaminergic Neurogenesis
Dopaminergic Neurogenesis
Dopaminergic Neurogenesis
Dopaminergic Neurogenesis
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (84)
1 – 10 of 84
MSX1
Tbio
Family: TF
Novelty: 0.00176212
Score: 0.93
Data Source: STRINGDB
NR4A2
Tchem
Family: NR
Novelty: 0.00204712
Score: 0.87
Data Source: STRINGDB
FOXA2
Tbio
Family: TF
Novelty: 0.00244521
Score: 0.781
Data Source: STRINGDB
OTX2
Tbio
Family: TF
Novelty: 0.0024536
Score: 0.774
Data Source: STRINGDB
WNT1
Tbio
Novelty: 0.00124301
Score: 0.748
Data Source: STRINGDB
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
Score: 0.734
Data Source: STRINGDB
LDB1
Tbio
Novelty: 0.01110112
Score: 0.725
Data Source: STRINGDB
ASCL1
Tbio
Family: TF
Novelty: 0.00274239
Score: 0.704
Data Source: STRINGDB
NEUROG2
Tbio
Family: TF
Novelty: 0.00489481
Score: 0.695
Data Source: STRINGDB
NKX6-1
Tbio
Family: TF
Novelty: 0.00776559
Score: 0.687
Data Source: STRINGDB
Publication Statistics
PubMed Score  104.99

PubMed score by year
PubTator Score  50.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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