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Tbio
PANK1
Pantothenate kinase 1

Protein Summary
Description
Plays a role in the physiological regulation of the intracellular CoA concentration. This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307534
  • ENSP00000302108
  • ENSG00000152782
  • ENST00000322191
  • ENSP00000318526
  • ENST00000342512
  • ENSP00000345118

Symbol
  • PANK
  • PANK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
molecular function
0.88
kinase perturbation
0.84
transcription factor binding site profile
0.84
microRNA
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.9   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.9   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
4
57.1
hematocrit
1
1
1
50.6
platelet crit
1
1
1
38.2
electrocardiography
1
1
6
33.1
mean corpuscular volume
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
57.1
hematocrit
1
50.6
platelet crit
1
38.2
electrocardiography
6
33.1
mean corpuscular volume
1
31.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pantothenate kinase 1
VGNC:12414
450590
Macaque
pantothenate kinase 1
696041
Mouse
MGI:1922985
75735
Dog
pantothenate kinase 1
486790
Cow
pantothenate kinase 1
VGNC:32563
535887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pantothenate kinase 1
Macaque
pantothenate kinase 1
Mouse
Dog
pantothenate kinase 1
Cow
pantothenate kinase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TE04-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Coenzyme A biosynthesis (R-HSA-196783)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Coenzyme A biosynthesis
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B5 (pantothenate) metabolism
Name
Explore in Pharos
Explore in Source
Coenzyme A biosynthesis
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B5 (pantothenate) metabolism
Protein-Protein Interactions (43)
1 – 10 of 43
SCD
Tchem
Family:  Enzyme
Novelty:  0.00063325
p_int:  0.999900689
p_ni:  0.000099304
p_wrong:  7e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
COASY
Tbio
Family:  Enzyme
Novelty:  0.00294867
Score:  0.986
Data Source:  STRINGDB
PPCS
Tbio
Family:  Enzyme
Novelty:  0.03813202
Score:  0.977
Data Source:  STRINGDB
PPCDC
Tbio
Family:  Enzyme
Novelty:  0.0322534
Score:  0.971
Data Source:  STRINGDB
ENPP1
Tchem
Family:  Enzyme
Novelty:  0.00256132
Score:  0.902
Data Source:  STRINGDB
ENPP3
Tchem
Family:  Enzyme
Novelty:  0.00414129
Score:  0.902
Data Source:  STRINGDB
VNN2
Tbio
Novelty:  0.02286648
Score:  0.819
Data Source:  STRINGDB
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
Score:  0.801
Data Source:  STRINGDB
SLC16A12
Tbio
Family:  Transporter
Novelty:  0.06883837
Score:  0.799
Data Source:  STRINGDB
C19orf12
Tbio
Novelty:  0.02182564
Score:  0.739
Data Source:  STRINGDB
Publication Statistics
PubMed Score  112.90

PubMed score by year
PubTator Score  15.83

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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