Tbio PANK1 Pantothenate kinase 1

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Type Ii Pantothenate Kinase Family / Pantothenate Kinase 1

Protein Summary

Description

Plays a role in the physiological regulation of the intracellular CoA concentration. This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]

Uniprot Accession IDs

• Q8TE04
• A6NIP0
• Q7RTX6
• Q7Z495
• Q8TBQ8
• hPanK

Gene Name

• PANK1

Ensembl ID

• ENST00000307534
• ENSP00000302108
• ENSG00000152782
• ENST00000322191
• ENSP00000318526
• ENST00000342512
• ENSP00000345118

Symbol

• PANK
• PANK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
molecular function	0.88
kinase perturbation	0.84
transcription factor binding site profile	0.84
microRNA	0.83

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.9   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 229   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.9   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (7)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3	3	4		57.1
hematocrit	EFO_0004348	1	1	1		50.6
platelet crit	EFO_0007985	1	1	1		38.2
electrocardiography	EFO_0004327	1	1	6		33.1
mean corpuscular volume	EFO_0004526	1	1	1		31.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	4		57.1
hematocrit	EFO_0004348	1		50.6
platelet crit	EFO_0007985	1		38.2
electrocardiography	EFO_0004327	6		33.1
mean corpuscular volume	EFO_0004526	1		31.4

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Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pantothenate kinase 1	VGNC:12414	450590
Macaque	pantothenate kinase 1		696041
Mouse	pantothenate kinase 1	MGI:1922985	75735
Dog	pantothenate kinase 1		486790
Cow	pantothenate kinase 1	VGNC:32563	535887

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pantothenate kinase 1
Macaque	pantothenate kinase 1
Mouse	pantothenate kinase 1
Dog	pantothenate kinase 1
Cow	pantothenate kinase 1

Protein Structure (2 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TE04-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (9)

Reactome (5)

KEGG (2)

PathwayCommons (1)

UniProt (1)

Coenzyme A biosynthesis (R-HSA-196783)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Coenzyme A biosynthesis	8 targets	R-HSA-196783
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Reactome	Metabolism of water-soluble vitamins and cofactors	122 targets	R-HSA-196849
Reactome	Vitamin B5 (pantothenate) metabolism	17 targets	R-HSA-199220

Name	Explore in Pharos	Explore in Source
Coenzyme A biosynthesis	8 targets	R-HSA-196783
Metabolism	2112 targets	R-HSA-1430728
Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	122 targets	R-HSA-196849
Vitamin B5 (pantothenate) metabolism	17 targets	R-HSA-199220

Gene Ontology Terms (11)

Functions (4)

Components (5)

Processes (2)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
acetyl-CoA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
pantothenate kinase activity	Traceable Author Statement (TAS)	Reactome
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

• See Interactions on String-DB

SCD

Tchem

Family:  Enzyme

Novelty:  0.00063325

p_int:  0.999900689

p_ni:  0.000099304

p_wrong:  7e-9

Score:  0.208

Data Source:  BioPlex,STRINGDB

COASY

Tbio

Family:  Enzyme

Novelty:  0.00294867

Score:  0.986

Data Source:  STRINGDB

PPCS

Tbio

Family:  Enzyme

Novelty:  0.03813202

Score:  0.977

Data Source:  STRINGDB

PPCDC

Tbio

Family:  Enzyme

Novelty:  0.0322534

Score:  0.971

Data Source:  STRINGDB

ENPP1

Tchem

Family:  Enzyme

Novelty:  0.00256132

Score:  0.902

Data Source:  STRINGDB

ENPP3

Tchem

Family:  Enzyme

Novelty:  0.00414129

Score:  0.902

Data Source:  STRINGDB

VNN2

Tbio

Novelty:  0.02286648

Score:  0.819

Data Source:  STRINGDB

VNN1

Tchem

Family:  Enzyme

Novelty:  0.0144646

Score:  0.801

Data Source:  STRINGDB

SLC16A12

Tbio

Family:  Transporter

Novelty:  0.06883837

Score:  0.799

Data Source:  STRINGDB

C19orf12

Tbio

Novelty:  0.02182564

Score:  0.739

Data Source:  STRINGDB

Publication Statistics

PubMed Score  112.90

PubMed score by year

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PubTator Score  15.83

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ATP-binding
Coenzyme A biosynthesis
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
electrocardiography
erythrocyte count
hematocrit
mathematical ability
mean corpuscular volume
platelet crit
red blood cell density measurement

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype