PANK1
Pantothenate kinase 1
Protein Summary
Plays a role in the physiological regulation of the intracellular CoA concentration. This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]
- ENST00000307534
- ENSP00000302108
- ENSG00000152782
- ENST00000322191
- ENSP00000318526
- ENST00000342512
- ENSP00000345118
- PANK
- PANK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
molecular function | 0.88 | ||
kinase perturbation | 0.84 | ||
transcription factor binding site profile | 0.84 | ||
microRNA | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.9 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 229 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.9 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 229 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (43)
SCD
Family: Enzyme
Novelty: 0.00063325
p_int: 0.999900689
p_ni: 0.000099304
p_wrong: 7e-9
Score: 0.208
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (5)
KEGG (2)
PathwayCommons (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Coenzyme A biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Reactome | Vitamin B5 (pantothenate) metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Coenzyme A biosynthesis | ||||
Metabolism | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Vitamin B5 (pantothenate) metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 3 | 4 | 57.1 | |||||
hematocrit | 1 | 1 | 1 | 50.6 | |||||
platelet crit | 1 | 1 | 1 | 38.2 | |||||
electrocardiography | 1 | 1 | 6 | 33.1 | |||||
mean corpuscular volume | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 57.1 | |||||
hematocrit | 1 | 50.6 | |||||
platelet crit | 1 | 38.2 | |||||
electrocardiography | 6 | 33.1 | |||||
mean corpuscular volume | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pantothenate kinase 1 | VGNC:12414 | 450590 | |||||
Macaque | pantothenate kinase 1 | 696041 | ||||||
Mouse | MGI:1922985 | 75735 | ||||||
Dog | pantothenate kinase 1 | 486790 | ||||||
Cow | pantothenate kinase 1 | VGNC:32563 | 535887 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pantothenate kinase 1 | |||||
Macaque | pantothenate kinase 1 | |||||
Mouse | ||||||
Dog | pantothenate kinase 1 | |||||
Cow | pantothenate kinase 1 | |||||
Publication Statistics
PubMed Score 112.90
PubMed score by year
PubTator Score 15.83
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (16)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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