ASAP3
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Protein Summary
Promotes cell proliferation. This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
- ENST00000336689
- ENSP00000338769
- ENSG00000088280
- ENST00000437606
- ENSP00000408826
- ENST00000495646
- ENSP00000436150
- ENST00000634513
- ENSP00000488934
- ENSG00000282854
- ENST00000634561
- ENSP00000488946
- ENST00000635198
- ENSP00000488953
- DDEFL1
- UPLC1
- ACAP4
- UPLC1
- CENTB6
- DDEFL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
histone modification site profile | 0.81 | ||
cell type or tissue | 0.65 | ||
tissue sample | 0.6 | ||
transcription factor binding site profile | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.29 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.29 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0