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Tdark
ACTRT2
Actin-related protein T2

Protein Summary
Description
The protein encoded by this intronless gene belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378404
  • ENSP00000367658
  • ENSG00000169717

Symbol
  • ARPM2
  • ARPM2
  • ARPT2
  • Arp-T2
  • HARPM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
cell line
0.5
cell type or tissue
0.44
protein domain
0.41
protein complex
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
PDCL3
Tbio
Novelty:  0.05786581
p_int:  0.969497646
p_ni:  0.030502354
Data Source:  BioPlex
CAPZA3
Tdark
Novelty:  0.27080401
Score:  0.681
Data Source:  STRINGDB
UBQLNL
Tdark
Novelty:  0.48160388
Score:  0.664
Data Source:  STRINGDB
CCIN
Tbio
Novelty:  0.05318622
Score:  0.611
Data Source:  STRINGDB
SAAL1
Tdark
Novelty:  0.33089811
Score:  0.603
Data Source:  STRINGDB
ZBTB5
Tbio
Novelty:  0.50774653
Score:  0.602
Data Source:  STRINGDB
CCDC27
Tdark
Novelty:  1.27912281
Score:  0.577
Data Source:  STRINGDB
MYO1D
Tbio
Novelty:  0.03263543
Score:  0.563
Data Source:  STRINGDB
C1orf174
Tdark
Novelty:  4.20172485
Score:  0.557
Data Source:  STRINGDB
MYO5A
Tbio
Novelty:  0.00373224
Score:  0.553
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
3
4
95.6
mean platelet volume
3
1
3
83.2
mean reticulocyte volume
1
1
1
80.4
mean corpuscular hemoglobin concentration
1
1
1
80.4
mean corpuscular volume
1
1
1
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
4
95.6
mean platelet volume
3
83.2
mean reticulocyte volume
1
80.4
mean corpuscular hemoglobin concentration
1
80.4
mean corpuscular volume
1
79.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin related protein T2
VGNC:30
469468
Macaque
actin related protein T2
711475
Mouse
MGI:1920603
73353
Rat
RGD:1359657
298671
Dog
actin related protein T2
VGNC:37559
479581
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin related protein T2
Macaque
actin related protein T2
Mouse
Rat
Dog
actin related protein T2
Publication Statistics
PubMed Score 2.18
PubMed score by year
PubTator Score 1.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title