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Tbio
RB1CC1
RB1-inducible coiled-coil protein 1

Protein Summary
Description
Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000025008
  • ENSP00000025008
  • ENSG00000023287
  • ENST00000435644
  • ENSP00000396067

Symbol
  • KIAA0203
  • RBICC
  • CC1
  • ATG17
  • FIP200
  • PPP1R131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
virus perturbation
0.92
histone modification site profile
0.87
hub protein
0.85
biological process
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.53   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.53   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999999927
p_ni:  7.2e-8
Data Source:  BioPlex
ATG101
Tbio
Novelty:  0.03407206
p_int:  0.999999925
p_ni:  7.4e-8
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
FAM221B
Tdark
Novelty:  71
p_int:  0.999999908
p_ni:  9.2e-8
Score:  0.23
Data Source:  BioPlex,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999999807
p_ni:  1.93e-7
Data Source:  BioPlex
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999986142
p_ni:  0.000013858
Score:  0.224
Data Source:  BioPlex,STRINGDB
DENR
Tbio
Novelty:  0.00653432
p_int:  0.999971327
p_ni:  0.000028673
Data Source:  BioPlex
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999770897
p_ni:  0.000229103
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999731344
p_ni:  0.000268656
Data Source:  BioPlex
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.991256287
p_ni:  0.008743712
p_wrong:  1e-9
Score:  0.265
Data Source:  BioPlex,STRINGDB
ULK1
Tchem
Family:  Kinase
Novelty:  0.00240301
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (358)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
8.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RB1 inducible coiled-coil 1
VGNC:3004
464173
Macaque
RB1 inducible coiled-coil 1
710330
Mouse
MGI:1341850
12421
Rat
RGD:1309346
312927
Dog
RB1 inducible coiled-coil 1
VGNC:45390
477876
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RB1 inducible coiled-coil 1
Macaque
RB1 inducible coiled-coil 1
Mouse
Rat
Dog
RB1 inducible coiled-coil 1
Publication Statistics
PubMed Score 155.53
PubMed score by year
PubTator Score 66.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title