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Tchem
NEK7
Serine/threonine-protein kinase Nek7

Protein Summary
Description
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367383
  • ENSP00000356353
  • ENSG00000151414
  • ENST00000367385
  • ENSP00000356355
  • ENST00000538004
  • ENSP00000444621
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
molecular function
0.93
disease perturbation
0.9
transcription factor binding site profile
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.34   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 332   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.34   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL475251
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1.6
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (R-HSA-2980767)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NIMA Kinases NEK9, NEK6, NEK7
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
M Phase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Activation of NIMA Kinases NEK9, NEK6, NEK7
Cell Cycle
Cell Cycle, Mitotic
M Phase
Mitotic Prophase
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (102)
1 – 10 of 102
NEK6
Tchem
Family: Kinase
Novelty: 0.02394134
p_int: 0.999999888
p_ni: 3.1e-8
p_wrong: 8.1e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
LAMP3
Tbio
Novelty: 0.01677383
p_int: 0.999900334
p_ni: 0.000099665
p_wrong: 1e-9
Data Source: BioPlex
ZNF669
Tdark
Family: TF
Novelty: 2.09725685
p_int: 0.994415839
p_ni: 0.005584158
p_wrong: 4e-9
Data Source: BioPlex
TNF
Tclin
Novelty: 0.00001457
p_int: 0.973352473
p_ni: 0.02658634
p_wrong: 0.000061187
Score: 0.161
Data Source: BioPlex,STRINGDB
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.97300754
p_ni: 0.026965146
p_wrong: 0.000027313
Data Source: BioPlex
ZNF214
Tbio
Family: TF
Novelty: 0.15323721
p_int: 0.971224357
p_ni: 0.028744849
p_wrong: 0.000030793
Score: 0.187
Data Source: BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.970549594
p_ni: 0.029443431
p_wrong: 0.000006976
Data Source: BioPlex
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.962228166
p_ni: 0.037750701
p_wrong: 0.000021133
Data Source: BioPlex
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.941130536
p_ni: 0.028220463
p_wrong: 0.030649
Score: 0.165
Data Source: BioPlex,STRINGDB
ELOA2
Tdark
Family: Enzyme
Novelty: 0.7420148
p_int: 0.920113658
p_ni: 0.079886211
p_wrong: 1.32e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  41.34

PubMed score by year
PubTator Score  24.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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