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Tbio
ACMSD
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Protein Summary
Description
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356140
  • ENSP00000348459
  • ENSG00000153086
  • ENST00000392928
  • ENSP00000376659
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
chemical
0.5
virus perturbation
0.5
metabolite
0.45
biological process
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.06   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.06   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
2
2
2
74.7
red blood cell density measurement
1
1
1
68.8
blood metabolite measurement
1
1
1
47.1
hematocrit
1
1
1
42.1
diastolic blood pressure
1
1
1
39.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
2
74.7
red blood cell density measurement
1
68.8
blood metabolite measurement
1
47.1
hematocrit
1
42.1
diastolic blood pressure
1
39.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminocarboxymuconate semialdehyde decarboxylase
VGNC:50
459627
Macaque
aminocarboxymuconate semialdehyde decarboxylase
708917
Mouse
MGI:2386323
266645
Rat
RGD:620868
171385
Dog
aminocarboxymuconate semialdehyde decarboxylase
VGNC:37512
476125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminocarboxymuconate semialdehyde decarboxylase
Macaque
aminocarboxymuconate semialdehyde decarboxylase
Mouse
Rat
Dog
aminocarboxymuconate semialdehyde decarboxylase
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Tryptophan catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Tryptophan catabolism
Protein-Protein Interactions (58)
1 – 10 of 58
CDK20
Tbio
Family: Kinase
Novelty: 0.01176977
p_int: 0.992117716
p_ni: 0.004433173
p_wrong: 0.003449112
Score: 0.517
Data Source: BioPlex,STRINGDB
HAAO
Tbio
Family: Enzyme
Novelty: 0.02869073
Score: 0.991
Data Source: STRINGDB
KYNU
Tchem
Family: Enzyme
Novelty: 0.01372383
Score: 0.919
Data Source: STRINGDB
KMO
Tchem
Family: Enzyme
Novelty: 0.01469543
Score: 0.915
Data Source: STRINGDB
MCCC1
Tbio
Family: Enzyme
Novelty: 0.01234441
Score: 0.875
Data Source: STRINGDB
TDO2
Tchem
Family: Enzyme
Novelty: 0.00115832
Score: 0.857
Data Source: STRINGDB
CCDC62
Tbio
Novelty: 0.1399166
Score: 0.793
Data Source: STRINGDB
QPRT
Tbio
Family: Enzyme
Novelty: 0.00781554
Score: 0.789
Data Source: STRINGDB
HIP1R
Tbio
Novelty: 0.02502713
Score: 0.702
Data Source: STRINGDB
STK39
Tbio
Family: Kinase
Novelty: 0.00548476
Score: 0.688
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.06

PubMed score by year
PubTator Score  19.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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