You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GPR151
Probable G-protein coupled receptor 151

Protein Summary
Description
Orphan receptor. This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311104
  • ENSP00000308733
  • ENSG00000173250

Symbol
  • PGR7
  • GPCR
  • PGR7
  • GALR4
  • GALRL
  • GPCR-2037
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.62
cell type or tissue
0.61
tissue
0.56
cell line
0.55
cellular component
0.35


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
53.2
self reported educational attainment
1
1
1
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
53.2
self reported educational attainment
1
6.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 151
VGNC:4019
471686
Macaque
G protein-coupled receptor 151
708020
Mouse
MGI:2441887
240239
Rat
RGD:727873
307475
Dog
G protein-coupled receptor 151
VGNC:41405
487201
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 151
Macaque
G protein-coupled receptor 151
Mouse
Rat
Dog
G protein-coupled receptor 151
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (38)
1 – 10 of 38
TCERG1
Tbio
Novelty: 0.01721248
Score: 0.69
Data Source: STRINGDB
GAL
Tbio
Novelty: 0.0005132
Score: 0.663
Data Source: STRINGDB
ADGRD1
Tbio
Family: GPCR
Novelty: 0.08106046
Score: 0.618
Data Source: STRINGDB
ENO2
Tbio
Family: Enzyme
Novelty: 0.00016748
Score: 0.574
Data Source: STRINGDB
ODF3
Tbio
Novelty: 0.08747036
Score: 0.571
Data Source: STRINGDB
RPS7
Tbio
Novelty: 0.00745987
Score: 0.559
Data Source: STRINGDB
SH3RF2
Tbio
Family: Enzyme
Novelty: 0.14257663
Score: 0.545
Data Source: STRINGDB
GNG8
Tdark
Novelty: 0.00590503
Score: 0.54
Data Source: STRINGDB
KCTD16
Tbio
Novelty: 0.09898256
Score: 0.539
Data Source: STRINGDB
RBM27
Tdark
Novelty: 0.04875536
Score: 0.537
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.91

PubMed score by year
PubTator Score  3.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer