Tbio RXFP4 Relaxin-3 receptor 2

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Relaxin-3 Receptor 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Relaxin-3 Receptor 2

Protein Summary

Description

High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8TDU9
• B0M0L4
• Q3MJB1
• Q8NGZ8
• RLN3 receptor 2

Gene Name

• RXFP4

Ensembl ID

• ENST00000368318
• ENSP00000357301
• ENSG00000173080

Symbol

• GPR100
• RLN3R2
• GPR100
• RLN3R2
• RXFPR4
• GPCR142

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.57
tissue	0.53
ligand (protein)	0.46
metabolite	0.45
molecular function	0.45

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	relaxin family peptide/INSL5 receptor 4	VGNC:9456	742539
Macaque	relaxin/insulin like family peptide receptor 4		718025
Mouse	relaxin family peptide receptor 4	MGI:2182926	242093
Horse	relaxin family peptide/INSL5 receptor 4	VGNC:22638	100063783
Opossum	relaxin/insulin like family peptide receptor 4 [Source:HGNC Symbol;Acc:HGNC:14666]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	relaxin family peptide/INSL5 receptor 4
Macaque	relaxin/insulin like family peptide receptor 4
Mouse	relaxin family peptide receptor 4
Horse	relaxin family peptide/INSL5 receptor 4
Opossum	relaxin/insulin like family peptide receptor 4 [Source:HGNC Symbol;Acc:HGNC:14666]

Pathways (10)

Reactome (8)

KEGG (2)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Peptide ligand-binding receptors	189 targets	R-HSA-375276

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Peptide ligand-binding receptors	189 targets	R-HSA-375276

Gene Ontology Terms (7)

Functions (2)

Components (2)

Processes (3)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
G protein-coupled peptide receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
galanin receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (248)

Explore Interacting Targets

1 – 10 of 248

• See Interactions on String-DB

RMND1

Tbio

Novelty: 0.06181833

p_int: 0.955343375

p_ni: 0.044656625

p_wrong: 1e-9

Score: 0.239

Data Source: BioPlex,STRINGDB

SC5D

Tbio

Family: Enzyme

Novelty: 0.02446366

p_int: 0.84360602

p_ni: 0.155857625

p_wrong: 0.000536355

Score: 0.269

Data Source: BioPlex,STRINGDB

RLN3

Tbio

Novelty: 0.0107593

Score: 0.993

Data Source: Reactome,STRINGDB

INSL5

Tbio

Novelty: 0.04351334

Score: 0.989

Data Source: Reactome,STRINGDB

RXFP1

Tchem

Family: GPCR

Novelty: 0.00580827

Score: 0.976

Data Source: STRINGDB

RXFP2

Tbio

Family: GPCR

Novelty: 0.00932189

Score: 0.969

Data Source: STRINGDB

KNG1

Tchem

Novelty: 0.00007684

Score: 0.949

Data Source: STRINGDB

HTR1E

Tchem

Family: GPCR

Novelty: 0.02160816

Score: 0.931

Data Source: STRINGDB

LPAR3

Tchem

Family: GPCR

Novelty: 0.00590837

Score: 0.929

Data Source: STRINGDB

P2RY14

Tchem

Family: GPCR

Novelty: 0.0135462

Score: 0.924

Data Source: STRINGDB

Publication Statistics

PubMed Score  21.28

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PubTator Score  21.05

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Cell membrane
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Disulfide bond
G-protein coupled receptor
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