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Tbio
RXFP4
Relaxin-3 receptor 2

Protein Summary
Description
High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368318
  • ENSP00000357301
  • ENSG00000173080

Symbol
  • GPR100
  • RLN3R2
  • GPR100
  • RLN3R2
  • RXFPR4
  • GPCR142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.57
tissue
0.53
ligand (protein)
0.46
metabolite
0.45
molecular function
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.74   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.74   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (248)
1 – 10 of 248
RMND1
Tbio
Novelty: 0.0888137
p_int: 0.955343375
p_ni: 0.044656625
p_wrong: 1e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
SC5D
Tbio
Family: Enzyme
Novelty: 0.04885876
p_int: 0.84360602
p_ni: 0.155857625
p_wrong: 0.000536355
Score: 0.269
Data Source: BioPlex,STRINGDB
RLN3
Tbio
Novelty: 0.01243441
Score: 0.993
Data Source: Reactome,STRINGDB
INSL5
Tbio
Novelty: 0.03673832
Score: 0.989
Data Source: Reactome,STRINGDB
RXFP1
Tchem
Family: GPCR
Novelty: 0.00590091
Score: 0.976
Data Source: STRINGDB
RXFP2
Tbio
Family: GPCR
Novelty: 0.01111071
Score: 0.969
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00008572
Score: 0.949
Data Source: STRINGDB
HTR1E
Tchem
Family: GPCR
Novelty: 0.02388691
Score: 0.931
Data Source: STRINGDB
LPAR3
Tchem
Family: GPCR
Novelty: 0.00724581
Score: 0.929
Data Source: STRINGDB
P2RY14
Tchem
Family: GPCR
Novelty: 0.02096508
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.74

PubMed score by year
PubTator Score  21.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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