Tbio RXFP4 Relaxin-3 receptor 2

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Relaxin-3 Receptor 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Relaxin-3 Receptor 2

Protein Summary

Description

High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8TDU9
• B0M0L4
• Q3MJB1
• Q8NGZ8
• RLN3 receptor 2

Gene Name

• RXFP4

Ensembl ID

• ENST00000368318
• ENSP00000357301
• ENSG00000173080

Symbol

• GPR100
• RLN3R2
• GPR100
• RLN3R2
• RXFPR4
• GPCR142

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.57
tissue	0.53
ligand (protein)	0.46
metabolite	0.45
molecular function	0.45

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.74   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.74   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (10)

Reactome (8)

KEGG (2)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Peptide ligand-binding receptors	189 targets	R-HSA-375276

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Peptide ligand-binding receptors	189 targets	R-HSA-375276

Gene Ontology Terms (7)

Functions (2)

Components (2)

Processes (3)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
G protein-coupled peptide receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
galanin receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (248)

Explore Interacting Targets

1 – 10 of 248

• See Interactions on String-DB

RMND1

Tbio

Novelty: 0.0888137

p_int: 0.955343375

p_ni: 0.044656625

p_wrong: 1e-9

Score: 0.239

Data Source: BioPlex,STRINGDB

SC5D

Tbio

Family: Enzyme

Novelty: 0.04885876

p_int: 0.84360602

p_ni: 0.155857625

p_wrong: 0.000536355

Score: 0.269

Data Source: BioPlex,STRINGDB

RLN3

Tbio

Novelty: 0.01243441

Score: 0.993

Data Source: Reactome,STRINGDB

INSL5

Tbio

Novelty: 0.03673832

Score: 0.989

Data Source: Reactome,STRINGDB

RXFP1

Tchem

Family: GPCR

Novelty: 0.00590091

Score: 0.976

Data Source: STRINGDB

RXFP2

Tbio

Family: GPCR

Novelty: 0.01111071

Score: 0.969

Data Source: STRINGDB

KNG1

Tchem

Novelty: 0.00008572

Score: 0.949

Data Source: STRINGDB

HTR1E

Tchem

Family: GPCR

Novelty: 0.02388691

Score: 0.931

Data Source: STRINGDB

LPAR3

Tchem

Family: GPCR

Novelty: 0.00724581

Score: 0.929

Data Source: STRINGDB

P2RY14

Tchem

Family: GPCR

Novelty: 0.02096508

Score: 0.924

Data Source: STRINGDB

Publication Statistics

PubMed Score  17.74

PubMed score by year

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PubTator Score  21.05

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MPTLNTSASPPTFFWANASGGSVLSADDAPMPVKFLALRLMVALAYGLVGAIGLLGNLAVLWVLSNCARR

1-70

APGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGGALCKMVLTATVLNVYASIFLITALSVARY

70-140

WVVAMAAGPGTHLSLFWARIATLAVWAAAALVTVPTAVFGVEGEVCGVRLCLLRFPSRYWLGAYQLQRVV

140-210

LAFMVPLGVITTSYLLLLAFLQRRQRRRQDSRVVARSVRILVASFFLCWFPNHVVTLWGVLVKFDLVPWN

210-280

STFYTIQTYVFPVTTCLAHSNSCLNPVLYCLLRREPRQALAGTFRDLRLRLWPQGGGWVQQVALKQVGRR

280-350

WVASNPRESRPSTLLTNLDRGTPG

350-374

MPTLNTSASPPTFFWANASGGSVLSADDAPMPVKFLALRLMVALAYGLVGAIGLLGNLAVLWVLSNCARRAPGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGGALCKMVLTATVLNVYASIFLITALSVARYWVVAMAAGPGTHLSLFWARIATLAVWAAAALVTVPTAVFGVEGEVCGVRLCLLRFPSRYWLGAYQLQRVVLAFMVPLGVITTSYLLLLAFLQRRQRRRQDSRVVARSVRILVASFFLCWFPNHVVTLWGVLVKFDLVPWNSTFYTIQTYVFPVTTCLAHSNSCLNPVLYCLLRREPRQALAGTFRDLRLRLWPQGGGWVQQVALKQVGRRWVASNPRESRPSTLLTNLDRGTPG

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Uniprot Keyword

Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer