Tchem RXFP4 Relaxin-3 receptor 2

Protein Summary

Description

High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8TDU9
• B0M0L4
• Q3MJB1
• Q8NGZ8
• RLN3 receptor 2

Gene Name

• RXFP4

Ensembl ID

• ENST00000368318
• ENSP00000357301
• ENSG00000173080

Symbol

• GPR100
• RLN3R2
• GPR100
• RLN3R2
• RXFPR4
• GPCR142

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.57
tissue	0.53
ligand (protein)	0.46
metabolite	0.45
molecular function	0.45

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Relaxin-3 Receptor 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Relaxin-3 Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.63   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.63   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0