Protein Summary
High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
- ENST00000368318
- ENSP00000357301
- ENSG00000173080
- GPR100
- RLN3R2
- GPR100
- RLN3R2
- RXFPR4
- GPCR142
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.57 | ||
tissue | 0.53 | ||
ligand (protein) | 0.46 | ||
metabolite | 0.45 | ||
molecular function | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.62 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 154 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.62 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 154 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (248)
Nearest Tclin Targets
Pathways (10)
Reactome (8)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 1 | 3 | 3 | 68.3 | |||||
body mass index | 2 | 2 | 2 | 61.4 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 61 | |||||
testosterone measurement | 2 | 2 | 2 | 55.8 | |||||
birth weight | 1 | 1 | 1 | 51.7 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 3 | 68.3 | |||||
body mass index | 2 | 61.4 | |||||
sex hormone-binding globulin measurement | 2 | 61 | |||||
testosterone measurement | 2 | 55.8 | |||||
birth weight | 1 | 51.7 | |||||
Find similar targets by:
IDG Resources
Reagents (1)
Genetic Construct
RXFP4-Tango
Details:
- Vector: addgene66495
- Vector backbone: pcDNA3.1(+)
- Promoter: CMV
- Tag: FLAG
Data:
- RXFP4-Tango
Order Genetic Construct from:
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | relaxin family peptide/INSL5 receptor 4 | VGNC:9456 | 742539 | |||||
Macaque | relaxin/insulin like family peptide receptor 4 | 718025 | ||||||
Mouse | MGI:2182926 | 242093 | ||||||
Horse | relaxin family peptide/INSL5 receptor 4 | VGNC:22638 | 100063783 | |||||
Opossum | relaxin/insulin like family peptide receptor 4 [Source:HGNC Symbol;Acc:HGNC:14666] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | relaxin family peptide/INSL5 receptor 4 | |||||
Macaque | relaxin/insulin like family peptide receptor 4 | |||||
Mouse | ||||||
Horse | relaxin family peptide/INSL5 receptor 4 | |||||
Opossum | relaxin/insulin like family peptide receptor 4 [Source:HGNC Symbol;Acc:HGNC:14666] | |||||
Publication Statistics
PubMed Score 21.62
PubMed score by year
PubTator Score 21.05
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (22)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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