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Tchem
RXFP4
Relaxin-3 receptor 2

Protein Summary
Description
High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368318
  • ENSP00000357301
  • ENSG00000173080

Symbol
  • GPR100
  • RLN3R2
  • GPR100
  • RLN3R2
  • RXFPR4
  • GPCR142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.57
tissue
0.53
ligand (protein)
0.46
metabolite
0.45
molecular function
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.62   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.62   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (248)
RMND1
Tbio
Novelty:  0.06181833
p_int:  0.955343375
p_ni:  0.044656625
p_wrong:  1e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
SC5D
Tbio
Family:  Enzyme
Novelty:  0.02446366
p_int:  0.84360602
p_ni:  0.155857625
p_wrong:  0.000536355
Score:  0.269
Data Source:  BioPlex,STRINGDB
RLN3
Tbio
Novelty:  0.0107593
Score:  0.993
Data Source:  Reactome,STRINGDB
INSL5
Tbio
Novelty:  0.04351334
Score:  0.989
Data Source:  Reactome,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
Score:  0.976
Data Source:  STRINGDB
RXFP2
Tbio
Family:  GPCR
Novelty:  0.00932189
Score:  0.969
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.949
Data Source:  STRINGDB
HTR1E
Tchem
Family:  GPCR
Novelty:  0.02160816
Score:  0.931
Data Source:  STRINGDB
LPAR3
Tchem
Family:  GPCR
Novelty:  0.00590837
Score:  0.929
Data Source:  STRINGDB
P2RY14
Tchem
Family:  GPCR
Novelty:  0.0135462
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
3
3
68.3
body mass index
2
2
2
61.4
sex hormone-binding globulin measurement
2
1
2
61
testosterone measurement
2
2
2
55.8
birth weight
1
1
1
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
68.3
body mass index
2
61.4
sex hormone-binding globulin measurement
2
61
testosterone measurement
2
55.8
birth weight
1
51.7
Find similar targets by:
IDG Resources
Genetic Construct
RXFP4-Tango
image for RXFP4-Tango
Details:
  • Vector:  addgene66495
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • RXFP4-Tango
Order Genetic Construct from:
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
relaxin family peptide/INSL5 receptor 4
VGNC:9456
742539
Macaque
relaxin/insulin like family peptide receptor 4
718025
Mouse
MGI:2182926
242093
Horse
relaxin family peptide/INSL5 receptor 4
VGNC:22638
100063783
Opossum
relaxin/insulin like family peptide receptor 4 [Source:HGNC Symbol;Acc:HGNC:14666]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
relaxin family peptide/INSL5 receptor 4
Macaque
relaxin/insulin like family peptide receptor 4
Mouse
Horse
relaxin family peptide/INSL5 receptor 4
Opossum
relaxin/insulin like family peptide receptor 4 [Source:HGNC Symbol;Acc:HGNC:14666]
Publication Statistics
PubMed Score 21.62
PubMed score by year
PubTator Score 21.05
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title