Tchem GPBAR1 G-protein coupled bile acid receptor 1

Protein Summary

Description

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TDU6
• B3KV35

Gene Name

• GPBAR1

Ensembl ID

• ENST00000479077
• ENSP00000430698
• ENSG00000179921
• ENST00000519574
• ENSP00000430202
• ENST00000521462
• ENSP00000428824
• ENST00000522678
• ENSP00000430886

Symbol

• TGR5
• BG37
• TGR5
• M-BAR
• GPCR19
• GPR131

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.63
biological term	0.57
cell line	0.57
tissue	0.57
chemical	0.53

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / G-protein Coupled Bile Acid Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Bile Acid Receptor / G-protein Coupled Bile Acid Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 566.98   (req: < 5)

Gene RIFs: 86   (req: <= 3)

Antibodies: 291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 566.98   (req: >= 5)

Gene RIFs: 86   (req: > 3)

Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 276

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2