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Tchem
GPBAR1
G-protein coupled bile acid receptor 1

Protein Summary
Description
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000479077
  • ENSP00000430698
  • ENSG00000179921
  • ENST00000519574
  • ENSP00000430202
  • ENST00000521462
  • ENSP00000428824
  • ENST00000522678
  • ENSP00000430886

Symbol
  • TGR5
  • BG37
  • TGR5
  • M-BAR
  • GPCR19
  • GPR131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.63
biological term
0.57
cell line
0.57
tissue
0.57
chemical
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 451.17   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 451.17   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 239
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
4
96.9
mean platelet volume
3
3
5
94.2
reticulocyte count
6
4
6
92.1
monocyte count
2
2
2
90.5
reticulocyte measurement
3
2
3
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
96.9
mean platelet volume
5
94.2
reticulocyte count
6
92.1
monocyte count
2
90.5
reticulocyte measurement
3
89
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled bile acid receptor 1
VGNC:50730
741111
Macaque
G protein-coupled bile acid receptor 1
697937
Mouse
MGI:2653863
227289
Rat
RGD:631400
338443
Horse
G protein-coupled bile acid receptor 1
VGNC:18482
100055590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled bile acid receptor 1
Macaque
G protein-coupled bile acid receptor 1
Mouse
Rat
Horse
G protein-coupled bile acid receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TDU6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Protein-Protein Interactions (168)
1 – 10 of 168
GCG
Tchem
Novelty:  0.00004879
Score:  0.969
Data Source:  STRINGDB
GIP
Tbio
Novelty:  0.0007219
Score:  0.955
Data Source:  STRINGDB
GLP1R
Tclin
Family:  GPCR
Novelty:  0.0006899
Score:  0.93
Data Source:  STRINGDB
GPR84
Tchem
Family:  GPCR
Novelty:  0.02360587
Score:  0.929
Data Source:  STRINGDB
SCT
Tbio
Novelty:  0.00070278
Score:  0.921
Data Source:  STRINGDB
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.92
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.917
Data Source:  STRINGDB
SCTR
Tclin
Family:  GPCR
Novelty:  0.01163942
Score:  0.917
Data Source:  STRINGDB
GIPR
Tchem
Family:  GPCR
Novelty:  0.00961809
Score:  0.916
Data Source:  STRINGDB
HTR7
Tclin
Family:  GPCR
Novelty:  0.00169884
Score:  0.916
Data Source:  STRINGDB
Publication Statistics
PubMed Score  451.17

PubMed score by year
PubTator Score  202.92

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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