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Tchem
MRGPRD
Mas-related G-protein coupled receptor member D

Protein Summary
Description
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309106
  • ENSP00000310631
  • ENSG00000172938

Symbol
  • MRGD
  • MRGD
  • TGR7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
cell line
0.64
protein domain
0.58
metabolite
0.45
tissue sample
0.4


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
&beta;-alanine
Rendered image for &beta;-alanine
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
3
0
1.5
98.1
hair colour measurement
1
1
1
87.2
heel bone mineral density
2
2
4
86.9
suntan
1
1
1
79.5
BMI-adjusted hip circumference
1
2
2
73.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.5
98.1
hair colour measurement
1
87.2
heel bone mineral density
4
86.9
suntan
1
79.5
BMI-adjusted hip circumference
2
73.4
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAS related GPR family member D
VGNC:12584
466686
Macaque
MAS related GPR family member D
709555
Mouse
MGI:3033142
211578
Rat
RGD:738040
293648
Cow
mas-related G-protein coupled receptor member D
615853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAS related GPR family member D
Macaque
MAS related GPR family member D
Mouse
Rat
Cow
mas-related G-protein coupled receptor member D
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TDS7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (27)
1 – 10 of 27
NPFF
Tbio
Novelty:  0.00489546
Score:  0.754
Data Source:  STRINGDB
TRPV1
Tclin
Family:  IC
Novelty:  0.00039493
Score:  0.71
Data Source:  STRINGDB
TRPA1
Tclin
Family:  IC
Novelty:  0.00093648
Score:  0.68
Data Source:  STRINGDB
TRPM8
Tclin
Family:  IC
Novelty:  0.00153949
Score:  0.654
Data Source:  STRINGDB
P2RX3
Tchem
Family:  IC
Novelty:  0.00203167
Score:  0.65
Data Source:  STRINGDB
SCN10A
Tclin
Family:  IC
Novelty:  0.00107685
Score:  0.583
Data Source:  STRINGDB
PIEZO2
Tbio
Family:  IC
Novelty:  0.00731622
Score:  0.573
Data Source:  STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
Score:  0.565
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.54
Data Source:  STRINGDB
SLC17A8
Tbio
Family:  Transporter
Novelty:  0.00647654
Score:  0.54
Data Source:  STRINGDB
Publication Statistics
PubMed Score  68.70

PubMed score by year
PubTator Score  14.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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