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Tchem
OXER1
Oxoeicosanoid receptor 1

Protein Summary
Description
Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378661
  • ENSP00000367930
  • ENSG00000162881

Symbol
  • GPR170
  • TG1019
  • GPCR
  • GPR170
  • TG1019
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
tissue sample
0.66
cell type or tissue
0.56
ligand (chemical)
0.51
pathway
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Genetic Construct
OXER1-Tango
image for OXER1-Tango
Details:
  • Vector:  addgene66465
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • OXER1-Tango
Order Genetic Construct from:
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
81.1
mean corpuscular volume
1
1
1
49.5
body mass index
1
1
1
38.2
platelet count
1
1
1
9.1
white matter hyperintensity measurement
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
81.1
mean corpuscular volume
1
49.5
body mass index
1
38.2
platelet count
1
9.1
white matter hyperintensity measurement
1
4.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxoeicosanoid receptor 1
VGNC:10728
737078
Macaque
oxoeicosanoid receptor 1
713039
Dog
oxoeicosanoid receptor 1
VGNC:44200
481349
Cow
oxoeicosanoid receptor 1
VGNC:32509
786807
Opossum
oxoeicosanoid receptor 1
100033380
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxoeicosanoid receptor 1
Macaque
oxoeicosanoid receptor 1
Dog
oxoeicosanoid receptor 1
Cow
oxoeicosanoid receptor 1
Opossum
oxoeicosanoid receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TDS5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (233)
1 – 10 of 233
GRM4
Tchem
Family:  GPCR
Novelty:  0.00380434
Score:  0.933
Data Source:  STRINGDB
HTR1E
Tchem
Family:  GPCR
Novelty:  0.02160816
Score:  0.925
Data Source:  STRINGDB
ADORA3
Tchem
Family:  GPCR
Novelty:  0.00089511
Score:  0.924
Data Source:  STRINGDB
TMIGD3
Tchem
Novelty:  0.00089511
Score:  0.924
Data Source:  STRINGDB
NPB
Tdark
Novelty:  0.00936692
Score:  0.922
Data Source:  STRINGDB
GNGT2
Tbio
Novelty:  0.0468008
Score:  0.917
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.915
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.915
Data Source:  STRINGDB
GNB5
Tbio
Novelty:  0.0067714
Score:  0.915
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.915
Data Source:  STRINGDB
Publication Statistics
PubMed Score  27.44

PubMed score by year
PubTator Score  9.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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